Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods

  • Mendel Friedman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 199)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Michael R. Gumbmann, William L. Spangler, Glenda M. Dugan, Joseph J. Rackis
    Pages 33-79
  3. R. G. H. Morgan, R. A. Crass, P. S. Oates
    Pages 81-89
  4. Roman S. Temler, Christine Mettraux
    Pages 133-141
  5. Walter Troll, Krystyna Frenkel, Rakoma Wiesner
    Pages 153-165
  6. Daniel Gallaher, Barbara O. Schneeman
    Pages 167-184
  7. Barbara O. Schneeman, Daniel Gallaher
    Pages 185-187
  8. J. P. Harwood, L. M. Ausman, N. W. King, P. K. Sehgal, R. J. Nicolosi, I. E. Liener et al.
    Pages 223-237
  9. Juergen K. P. Weder
    Pages 239-279
  10. Willis E. Brown, John S. Graham, Jong S. Lee, Clarence A. Ryan
    Pages 281-290
  11. J. J. Rackis, W. J. Wolf, E. C. Baker
    Pages 299-347
  12. Mendel Friedman, Michael R. Gumbmann
    Pages 357-389
  13. Anna L. Tan-Wilson, Karl A. Wilson
    Pages 391-411
  14. Barry Starcher, Leah Bryant, Michale Elfant
    Pages 429-438
  15. Thillaisthanam N. Pattabiraman
    Pages 439-448
  16. David L. Brandon, Sakhina Haque, Mendel Friedman
    Pages 449-467
  17. Back Matter
    Pages 561-572

About this book


Soybean protei ns are wi de 1 y used inhuman foods ina vari ety of forms, including baby formulas, flour, soy protein concentrates, soy protein isolates, soy sauces, textured soy fibers, and tofu. The presence of inhibitors of digestive enzymes in soy proteins impairs nutritional quality and possible safety of this impportant legume. Normal processing conditions based on the use of heat do not completely inactivate these inhibitors, so that residual amounts of plant protease inhibitors are consumed by animals and man. Inhibitors of digestive enzymes are present not only in legumes, such as soybeans, lima beans, and kidney beans, but also in nearly all plant foods, including cereals and potatoes, albeit in much smaller amounts. The antinutritional effects of inhibitors of proteolytic enzymes have been widely studied and can be ameliorated by processing and/or sulfur amino acid fortification. A more urgent concern is reports that rats fed diets containing even low levels of soybean-derived inhibitors, which are found in foods such as soy-based baby formulas, may develop over their lifespan pancreatic lesions leading eventually to neoplasia or tumor formation. On the other hand, recent stUdies suggest that certain enzyme inhibitors from plant foods may prevent cancer formation in other tissues. A key question, therefore, is whether inhibitors from plant foods constitute a human health hazard.


amino acid cancer cereals enzymes food health nutrition processing proteins soy

Editors and affiliations

  • Mendel Friedman
    • 1
  1. 1.U.S. Department of AgricultureBerkeleyUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-0024-4
  • Online ISBN 978-1-4757-0022-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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