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Purine Metabolism in Man, III

Biochemical, Immunological, and Cancer Research

  • Book
  • © 1980

Overview

Editors:
  1. Aurelio Rapado

    1. Fundación Jiménez Díaz, Madrid, Spain

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  2. R. W. E. Watts

    1. M.R.C. Clinical Research Centre, Harrow, England

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  3. Chris H. M. M. Bruyn

    1. Department of Human Genetics, University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 122B)

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Table of contents (71 chapters)

  1. Enzymology and Purine Metabolism

    2. Nucleoside Phosphoribosylating Enzymes

      1. Structural Studies of Human Adenine Phosphoribosyltransferase Purified by Affinity Chromatography
        • Joseph A. Holden, Gary S. Meredith, William N. Kelley
        Pages 123-129
      2. Phosphoribosylpyrophosphate (PRPP) Synthetase Mutant in <i>Salmonella typhimurium</i>
        • B. Jochimsen, B. Garber, J. S. Gots
        Pages 131-136

    3. Nucleoside Cleaving Enzymes

      1. Methylmercaptopurine Ribonucleoside Toxicity in Human Fibroblasts: Inhibition of Phosphoribosylpyrophosphate Synthetase as Well as Amidophosphoribosyltransferase
        • Richard C. K. Yen, Michael A. Becker
        Pages 137-143
      2. Adenosine Kinase: Regulation by Substrates, Magnesium and pH
        • Richard L. Miller, David L. Adamczyk
        Pages 145-149
      3. Adenosine and Deoxyadenosine Kinase from Rat Liver
        • Nobuaki Ogasawara, Yasukazu Yamada, Haruko Goto
        Pages 151-156

    4. Deaminating Enzymes

      1. Radioimmunochemical Analysis of Human Erythrocyte Adenosine Deaminase
        • Peter E. Daddona, Michael A. Frohman, William N. Kelley
        Pages 157-162
      2. Adenosine Deaminase Conversion Proteins: A Potential Role
        • Paul P. Trotta, M. Earl Balis
        Pages 163-168
      3. Regulatory Properties of AMP Deaminase Isozymes
        • Nobuaki Ogasawara, Haruko Goto, Yasukazu Yamada
        Pages 169-175
      4. Human Adenosine Deaminase: Stoichiometry of the Large form Complex
        • Peter E. Daddona, William N. Kelley
        Pages 177-181
      5. Guanase from Human Liver — Purification and Characterisation
        • Rudolf Kuzmits, Heinrich Stemberger, Mathias M. Müller
        Pages 183-188

    5. Oxidating Enzymes

      1. Nicotinamide and Liver Xanthine Oxdidase
        • A. Di Stefano, M. Pizzichini, E. Marinello
        Pages 189-196
      2. Xanthine Oxidase Activity in Human Intestines. Histochemical and Radiochemical Study
        • C. Auscher, N. Amory, P. van der Kemp, F. Delbarre
        Pages 197-201

  2. Pyrimidine Metabolism

    1. Purine and Pyrimidine Metabolism in Hereditary Oroticaciduria During a 15 Year Follow-Up Study

      • D. R. Webster, H. A. Simmonds, C. F. Potter, D. M. O. Becroft
      Pages 203-208

    2. Effect of Allopurinol on Pyrimidine Metabolism in Human White Blood Cells. Role of the Salvage Pathway

      • P. Banholzer, W. Gröbner, N. Zöllner
      Pages 209-215

    3. Kinetics and Compartmentation of Erythrocyte Pyrimidine Metabolism

      • E. H. Harley, P. Zetler, S. Neal
      Pages 217-222

    4. Simultaneous Determination of Rates of Purine and Pyrimidine Synthesis in Cultured Human Lymphoblasts and Fibroblasts

      • William H. Huisman, Kari O. Raivio, Michael A. Becker
      Pages 223-229

    5. Activities of Enzymes of Purine and Pyrimidine Metabolism in Nine Mycoplasma Species

      • M. Hamet, C. Bonissol, P. Cartier
      Pages 231-235
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Keywords

About this book

These volumes contain the papers which were presented at the Third International Symposium on Purine Metabolism in Man held in Madrid (Spain) in June, 1979. The previous meetings in the series were held in Tel Aviv (Israel) and in Baden (Austria) in 1973 and 1976, respectively. The proceedings were also published by Plenum. Knowledge of the pathophysiology of the purines has developed greatly since the 1950's when it was mainly related to clinical gout, and it is now relevant to many fields of Medicine and Biology. These volumes include papers reporting new work on clinical gout and urolithiasis as well as on some of the subjects which have featured prominently in the previous volumes, including: regulatory aspects of the intermediary metabolism of purines and related com­ pounds, enzymology, methodology, and the results of mutations which affect purine metabolism. However, there have been many new develop­ ments during the last three years and the scope of the communications reflects not only increasing depth of knowledge, but also a widening of the field. This publication has clinical and fundamental impli­ cations for internal medicine, pediatrics, urology, biochemistry, immunology, genetics, and oncology.

Editors and Affiliations

  • Fundación Jiménez Díaz, Madrid, Spain

    Aurelio Rapado

  • M.R.C. Clinical Research Centre, Harrow, England

    R. W. E. Watts

  • Department of Human Genetics, University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

    Chris H. M. M. Bruyn

Bibliographic Information

  • Book Title: Purine Metabolism in Man, III

  • Book Subtitle: Biochemical, Immunological, and Cancer Research

  • Editors: Aurelio Rapado, R. W. E. Watts, Chris H. M. M. Bruyn

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-8559-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1980

  • Softcover ISBN: 978-1-4684-8561-5Published: 26 November 2012

  • eBook ISBN: 978-1-4684-8559-2Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXII, 459

  • Number of Illustrations: 80 b/w illustrations

  • Topics: Biochemistry, general

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

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