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Mechanisms of Cell-Mediated Cytotoxicity II

  • Book
  • © 1985

Overview

Editors:
  1. Pierre Henkart

    1. National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Eric Martz

    1. University of Massachusetts, Amherst, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 184)

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Table of contents (36 chapters)

  1. NK Cell Mediated Cytotoxicity

    1. The Lipoxygenase Pathway in the Human NK Cell System

      • Mikael Jondal, Charlotte Kullman, Jan-Åke Lindgren, Paolo Rossi
      Pages 257-270

    2. A Serine Proteinase as a “Trigger” for Human Natural Killer Lymphocyte-Mediated Cytolysis

      • Dorothy Hudig, Lory Minning, Doug Redelman
      Pages 271-280

    3. The Mechanism of Leukoregulin Enhancement of Target Cell Susceptibility to NK Cell Mediated Cytotoxicity in Humans

      • Janet H. Ransom, Charles H. Evans, Richard P. McCabe, M. G. Hanna Jr.
      Pages 281-287

  2. The Role of Membrane Components in CTL Function

    1. Front Matter

      Pages 289-289
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    2. Lymphocyte Function-Associated Antigens: Regulation of Lymphocyte Adhesions in Vitro and Immunity in Vivo

      • Eric Martz, Stanislaw H. Gromkowski
      Pages 291-310

    3. The Function of LFA-1 in Cell-Mediated Killing and Adhesion: Studies on Heritable LFA-1, Mac-1 Deficiency and on Lymphoid Cell Self-Aggregation

      • Timothy A. Springer, Robert Rothlein, Donald C. Anderson, Steven J. Burakoff, Alan M. Krensky
      Pages 311-322

    4. Functional Interactions of LFA-1, T8 and Alloantigen Surface Structures in T-Cell Mediated Cytotoxicity

      • Carl F. Ware, Jeanne L. Reade
      Pages 323-341

    5. Requirement for LYT-2/3 Molecules on Allospecific Cytolytic T Lymphocyte Clones is Dependent Upon Target Cell Antigen Density

      • Richard Shimonkevitz, Jean-Charles Cerottini, H. Robson MacDonald
      Pages 343-353

    6. Functional Relationships of LYT-2 and LYT-3 Expression and T-Cell Cytotoxicity: A New Model System

      • Michael A. Palladino Jr., Gerald E. Ranges, Herbert F. Oettgen, Lloyd J. Old
      Pages 355-364

    7. The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity

      • Constantine D. Tsoukas, Mary Valentine, Martin Lotz, John H. Vaughan, Dennis A. Carson
      Pages 365-385

    8. The Plasma Membrane ‘Skeleton’ of Tumor and Lymphoid Cells: A Role in Cell Lysis?

      • Matthew F. Mescher, John R. Apgar
      Pages 387-400

    9. p215 and p24: Two Membrane-Associated Proteins Expressed on Cloned Cytolytic T-Cells but not on Cloned Helper T-Cells

      • Maurice K. Gately, Michael D. Dick, Tomiya Masuno, Richard M. McCarron, Beatrice Macchi
      Pages 401-413

    10. Mechanism of T-Dependent Cytotoxicity: Role of Papain-Sensitive Non Class I MHC Target Molecules and Expression of Target Antigen for Cytotoxicity

      • Benjamin Bonavida, Hanna Ostergaard, Jonathan Katz
      Pages 415-428

    11. Cell-Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular Cytotoxicity

      • Michail V. Sitkovsky, Martin A. Schwartz, Herman N. Eisen
      Pages 429-449

  3. Post-Binding Events in the Cytotoxic Process

    1. Front Matter

      Pages 451-451
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    2. Evidence for the Molecular Dissociation of Binding and Post-Binding Functions in Cytotoxic T Lymphocytes

      • John H. Russell, Rawleigh C. Howe
      Pages 453-472

    3. Immune Cytolysis Viewed as a Stimulatory Process of the Target

      • Reuven Tirosh, Gideon Berke
      Pages 473-492

    4. DNA Fragmentation in Targets of CTL: An Example of Programmed Cell Death in the Immune System

      • J. John Cohen, Richard C. Duke, Robert Chervenak, Karen S. Sellins, Lori K. Olson
      Pages 493-508

    5. Mechanism of Rapid Tumor Lysis by Human ADCC: Mediation by Monoclonal Antibodies and Fragmentation of Target Cell DNA

      • Duane W. Sears, Jeffrey E. Christiaansen
      Pages 509-525

    6. Cell Surface Thiols, Methylation, and Complement-Like Components are Involved in the Early Events of CML Whereas Proteases Participate in the Later, Ca++-Dependent Events

      • Doug Redelman, Dorothy Hudig
      Pages 527-534
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Keywords

About this book

This book is derived from contributions to the Second International Workshop on Mechanisms in Cell-Mediated Cytotoxicity, held in Annopolis, Maryland, June 10-13, 1984. This workshop was organized by an international committee of immunologists interested in lymphocyte cytotoxic mechanisms (G. Berke, W.R. Clark, P. Golstein, M. Hanna, P. Henkart, R. Herberman, H.R. MacDonald, E. Martz, and C. Nathan), who strove to invite participants who have made major contributions to this field. The Workshop was a follow-up to the highly successful 1981 Workshop, whose proceedings Workshop were published by Plenum as Mechanisms in Cell-Mediated Cytotoxicity, edited by W.R. Clark and P. Golstein. That volume has been much appreciated by researchers and students since it contains accounts of most of the current approaches to understanding cytotoxic lymphocyte mechanisms all in one volume. The present book may be viewed as a follow-up to the first one, and in our opinion fairly summarizes the varying current viewpoints on lymphocyte cytotoxic mechanism. It should be noted that the discussions have been transcribed directly by us, and the participants have not had an opportunity to edit their remarks. We have tried to maintain some of the style of the actual discussion in these transcripts. In some cases technical problems prevented usable transcriptions from being made, and hence not all of the actual discussion at the workshop is reproduced here.

Editors and Affiliations

  • National Institutes of Health, Bethesda, USA

    Pierre Henkart

  • University of Massachusetts, Amherst, USA

    Eric Martz

Bibliographic Information

  • Book Title: Mechanisms of Cell-Mediated Cytotoxicity II

  • Editors: Pierre Henkart, Eric Martz

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-8326-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1985

  • Softcover ISBN: 978-1-4684-8328-4Published: 26 November 2012

  • eBook ISBN: 978-1-4684-8326-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 568

  • Topics: Immunology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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