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New Trends in Pharmacokinetics

  • Aldo Rescigno
  • Ajit K. Thakur

Part of the NATO ASI Series book series (NSSA, volume 221)

Table of contents

  1. Front Matter
    Pages i-x
  2. Aldo Rescigno, Bianca Maria Bocchialini
    Pages 1-25
  3. James S. Beck
    Pages 27-39
  4. Ajit K. Thakur
    Pages 41-51
  5. D. Krewski, R. T. Burnett, W. Ross
    Pages 53-67
  6. Malcolm Rowland, Allan M. Evans
    Pages 83-102
  7. A. Bertrand Brill, Andrew Karellas
    Pages 125-147
  8. Alan J. Fischman, Robert H. Rubin, H. William Strauss
    Pages 149-167
  9. B. Mazière, M. Mazière, J. Delforge, A. Syrota
    Pages 169-187
  10. Giuliano Mariani, Luigi Ferrante, Aldo Rescigno
    Pages 189-202
  11. Kannan Krishnan, Melvin E. Andersen
    Pages 203-226
  12. Alberto Tajana
    Pages 227-255
  13. M. Eichelbaum, A. S. Gross
    Pages 271-279
  14. L. P. Balant, E. Doelker, P. Buri
    Pages 281-299
  15. Ajit K. Thakur, Arvind Parthasarathi
    Pages 301-314
  16. James T. Stevens, Darrell D. Sumner
    Pages 315-333
  17. Kannan Krishnan, Melvin E. Andersen
    Pages 335-354
  18. D. Krewski, J. R. Withey, L. F. Ku, C. C. Travis
    Pages 355-390
  19. L. P. Balant, A. E. Balant-Gorgia, M. Gex-Fabry, M. Eichelbaum
    Pages 391-410
  20. Back Matter
    Pages 425-440

About this book

Introduction

The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and pharmacokinetics in particular. Clinical pharmacokinetics is using new tools for probing into the "black box" once being ac­ cessible only partly through experimental techniques and, mostly through mathemati­ cal and computer means. Development of computerized scanning, positron emission tomography (PET), stereoselectivity and other techniques are now enabling investi­ gators to have better pictures of the systems they are studying. Mathematical models through computer simulation and statistical estimation, mostly due to easy access be­ cause of inexpensive yet powerful personal computers, are enabling us to investigate ultrastructures and their functional connectivity in more detail. As a consequence, new hypotheses are being formed and tested in various related fields. In clinical pharmacokinetics, mostly due to mathematical modeling, more accurate interspecies scaling of pharmacokinetic parameters and dosimetry can be done now-a-days. The concept of "a human is a bigger rat" does not necessarily fly as a consequence. Pharmacokinetic concepts are becoming powerful tools in meaningful carcinogenic and toxic risk extrapolation of different chemicals in humans. New dose delivery designs are being formulated using pharmacokinetic techniques for different pharmaceutical compounds. Investigations continue in the academia, research institutions, pharmaceutical, biotechnological, and agricultural industries in developmental and physiological aspects of different chemicals for the benefit of mankind. The idea of a school on "New Trends in Pharmacokinetics", from which the present pUblication was made possible, took shape over almost a year.

Keywords

drug drug development kinetics metabolism pharmacokinetics pharmacology receptor research

Editors and affiliations

  • Aldo Rescigno
    • 1
  • Ajit K. Thakur
    • 2
  1. 1.University of ParmaParmaItaly
  2. 2.Hazleton Washington, Inc.ViennaUSA

Bibliographic information

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Pharma
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