Carbohydrate Metabolism in Cultured Cells

  • Michael J. Morgan

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Herman M. Kalckar, Donna B. Ullrey
    Pages 1-27
  3. Michael J. Morgan, Pelin Faik
    Pages 29-75
  4. Wallace L. McKeehan
    Pages 111-150
  5. Gagik Stepan-Sarkissian, Michael W. Fowler
    Pages 151-181
  6. Juana M. Gancedo
    Pages 245-286
  7. William McCullough, Clive F. Roberts, Stephen A. Osmani, Michael C. Scrutton
    Pages 287-355
  8. Peter J. F. Henderson
    Pages 409-460
  9. Back Matter
    Pages 492-514

About this book


It is perhaps obvious to any student of Biology that the discovery of chemical processes in whole organisms has usually preceded the elucidation of the compo­ nent steps. However, it is perhaps less obvious that the unravelling of the se­ quences in which those chemical steps occur in living matter, of the precise mechanisms involved, and of the manner in which they are regulated, would have been achieved neither by the study of intact plants and animals nor even of extracts derived from them. Our ability to understand the nature and regulation of metabolism rests on two main premises: the postulate that life processes can indeed be validly investigated with individual cells and cell-free extracts, and the thesis that there is an essential "unity in biochemistry" (as Kluyver put it, 60 years ago) that enables events in one organism to be legitimately studied in another. Of particular utility in this latter respect has been the use of cultures of single-celled organisms, growing in defined media-especially prokaryotes, such as Escherichia coli, and eukaryotes, such as Neurospora and Sac­ charomyces sp. , to which both biochemical and genetical techniques could be applied. It was, of course, Pasteur's observations of bacterial fermentations that first overthrew the belief that oxygen was essential for all energy-yielding pro­ cesses: his recognition that "La fermentation . . . . . c' est La vie sans air" laid the foundations of our knowledge of glycolysis.


Amino acid Disaccharid Fructose Galactose Glutamin Monosaccharid Oxidation Polysaccharid biochemistry enzymes metabolism natural product transcription

Editors and affiliations

  • Michael J. Morgan
    • 1
  1. 1.Department of BiochemistryUniversity of LeicesterLeicesterEngland, UK

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