Molecular Mechanisms of Neuronal Responsiveness

  • Yigal H. Ehrlich
  • Robert H. Lenox
  • Elizabeth Kornecki
  • William O. Berry

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 221)

Table of contents

  1. Front Matter
    Pages i-x
  2. Signal Transduction and Stimulus-Response Coupling

    1. Howard Rasmussen, Paula Barrett
      Pages 19-31
    2. J. E. Kimura, B. McIver
      Pages 33-43
    3. Bernard W. Agranoff
      Pages 69-79
    4. M. W. Bitensky, D. Torney, A. Yamazaki, M. M. Whalen, J. S. George
      Pages 107-121
    5. M. M. Rasenick, M. M. Marcus, Y. Hatta, F. DeLeon-Jones, S. Hatta
      Pages 123-133
    6. Paul Greengard, Michael D. Browning, Teresa L. McGuinness, Rodolfo Llinas
      Pages 135-153
    7. Richard A. Lampe, Leonard G. Davis, Michael J. Gutnick
      Pages 201-210
    8. David M. Terrian, Scott B. Bischoff, Monica A. Schwartz, Robert V. Dorman
      Pages 237-251
  3. Neuronal Adaptation and Synaptic Plasticity

    1. David R. Sibley, Jeffrey L. Benovic, Marc G. Caron, Robert J. Lefkowitz
      Pages 253-273
    2. P. F. VonVoigtlander, M. Camacho Ochoa, R. A. Lewis
      Pages 345-355
    3. Judith Van Houten, Robin R. Preston
      Pages 375-384
    4. Jesus A. Angulo, Greg R. Christoph, Robert W. Manning, Beth A. Burkhart, Leonard G. Davis
      Pages 385-391
  4. Behavioral and Clinical Implications

    1. Louise H. Schrama, Pierre N. E. De Graan, A. Beate Oestreicher, Willem Hendrik Gispen
      Pages 393-408
    2. William C. Taft, James R. Goldenring, Robert J. DeLorenzo
      Pages 409-425
    3. William W. Pendlebury, David Munoz-Garcia, Daniel P. Perl
      Pages 427-442
    4. Hratchia Havoundjian, Ramon Trullas, Steven Paul, Phil Skolnick
      Pages 459-475
    5. K. G. Walton, T. McCorkle, T. Hauser, C. MacLean, R. K. Wallace, J. Ieni et al.
      Pages 503-514
  5. Back Matter
    Pages 557-563

About this book


The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep­ tor molecules have answered many quest ions regarding the nature of the ele­ ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus­ response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer­ ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis­ try, pharmacology, cell-biology, molecular genetics, neurology, and psy­ chiatry are required to achieve better understanding of the processes under­ lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu­ lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.


Ether Lipid Peptid Protein biology chemistry information isolation molecular genetics neurophysiology pharmacology physiology receptor receptors regulation

Editors and affiliations

  • Yigal H. Ehrlich
    • 1
  • Robert H. Lenox
    • 1
  • Elizabeth Kornecki
    • 1
  • William O. Berry
    • 2
  1. 1.The University of Vermont College of MedicineBurlingtonUSA
  2. 2.Bolling A.F. BaseU.S. Air Force Office of Scientific ResearchUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-7620-0
  • Online ISBN 978-1-4684-7618-7
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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