Free Radicals, Lipoproteins, and Membrane Lipids

  • A. Crastes de Paulet
  • L. Douste-Blazy
  • R. Paoletti

Part of the NATO ASI Series book series (NSSA, volume 189)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Free Radical Production Mechanisms

    1. Front Matter
      Pages xi-xi
    2. Wolf Bors, Michael Erben-Russ, Christa Michel, Manfred Saran
      Pages 1-16
    3. Bernard M. Babior
      Pages 17-21
    4. P. Bellavite, M. C. Serra, F. Bazzoni, S. Miron, S. Dusi
      Pages 23-44
    5. Monique Paubert-Braquet, David Hosford, Philipe Koltz, Jean Guilbaud, Pierre Braquet
      Pages 45-53
    6. Giovanni Ricevuti, Antonino Mazzone, Antonia Notario
      Pages 55-63
    7. Julio F. Turrens, Joe M. McCord
      Pages 65-71
    8. John W. Eaton, Douglas A. Peterson, S. M. H. Sadrzadeh
      Pages 73-79
    9. Matthew B. Grisham, Barbara J. Zimmerman, D. Neil Granger
      Pages 81-88
    10. Roberto Bolli, Bharat S. Patel, Mohamed O. Jeroudi, Edward K. Lai, Paul B. McCay
      Pages 89-97
    11. Ingrid Emerit, Arlette Levy, Shahid Khan
      Pages 99-104
  3. Chemistry of Free Radical Effects

    1. Front Matter
      Pages N1-N1
    2. C. Deby, M. Boes, J. Pincemail, J. Bourdon-Neuray, G. Deby-Dupont
      Pages 105-113
    3. Monique Gardès-Albert, Chantal Houée-Levin, Abdelhafid Sekaki, Christiane Ferradini
      Pages 133-142
  4. Methods of Measurement

    1. Front Matter
      Pages N3-N3
    2. Toshikazu Yoshikawa, Yuji Naito, Toru Tanigawa, Shigeru Sugino, Motoharu Kondo
      Pages 153-162
    3. J. Pincemail, C. Deby, M. Lismonde, Y. Bertrand, G. Camus, M. Lamy
      Pages 163-169
  5. Action on Model Systems and Cellular Structures

    1. Front Matter
      Pages N5-N5
    2. Mario Umberto Dianzani, Luciana Paradisi, Maurizio Parola, Giuseppina Barrera, Maria Armida Rossi
      Pages 171-181
    3. Giuseppe Poli, Elena Chiarpotto, Emanuele Albano, Fiorella Biasi, Damiano Cottalasso, Maria A. Pronzato et al.
      Pages 183-191
  6. Oxidized Lipoproteins and Atherogenesis

    1. Front Matter
      Pages N7-N7
    2. Martina Rotheneder, Georg Striegl, Hermann Esterbauer
      Pages 203-213
    3. David G. Cornwell, Hanfang Zhang, W. Bruce Davis, Ronald L. Whisler, Rao V. Panganamala
      Pages 215-237
    4. R. Salvayre, A. Nègre, M. Lopez, N. Dousset, T. Levade, A. Maret et al.
      Pages 249-256
  7. Biological Effects

    1. Front Matter
      Pages N9-N9
    2. Sten Orrenius
      Pages 257-267
    3. Leland L. Smith, Sontin Mossanda Kensese
      Pages 279-289
    4. A. Crastes de Paulet, M. E. Astruc, J. Bascoul, R. Defay
      Pages 291-300
    5. Kristin Olafsdottir, Åke Ryrfeldt, Margareta Berggren, Peter Moldéus
      Pages 301-307
    6. Roger Nordmann, Catherine Ribière, Hélène Rouach
      Pages 309-315
    7. J. C. Mazière, S. Salmon, C. Candide, C. Mazière, R. Santus, J. P. Reyftmann et al.
      Pages 327-342
    8. Charles G. Cochrane, Paul A. Hyslop, Janis H. Jackson, Ingrid U. Schraufstatter
      Pages 343-358
  8. Defense Mechanisms

  9. Back Matter
    Pages 399-409

About this book


This book contains the proceedings of the ARW NATO Conference on "Action of Free Radicals and Active Forms of Oxygen on Lipoproteins and Membrane Lipids: Cellular Interactions and Atherogenesis", held in Bendor, France, October 5-8,1988. Since the pioneer work of Mc Cord and Fridovitch, growing interest has been focused on the study of the role of oxyradicals role in pathology. This interest is reflected in the exponential increase in the number of papers on free radicals, the success of specialized journals and books on this theme, and the organization of national and international meetings. These meetings have discussed, from.a broad point of view, the problems concerning the mechanisms of production of free radicals, their effects on cell CO!1$tituants (lipids, proteins, nucleic acids) and cell function, the methods of analysis of these phenomena, the pathological states in which free radicals may be involved, natural biological defense systems, and the design of "antiradical" therapies. But it is now well established that the most common target of oxy free radicals are membrane lipids because of their chemical nature (cholesterol in saturation, malonic linkage of polyunsaturated fatty acids (PUFA» and of their regular structural arrangement (monolayers in lipoproteins, bilayers in cell membranes). Thus the analysis of the products resulting from the action of oxy free radicals on PUFA is considered the best tool to indirectly evaluate the effects of tissue peroxidations, although the analytical basis for doing so is very questionable.


Lipoprotein Oxidation cell membrane lipide nucleic acid protein proteins tissue

Editors and affiliations

  • A. Crastes de Paulet
    • 1
  • L. Douste-Blazy
    • 2
  • R. Paoletti
    • 3
  1. 1.INSERM Unit 58MontpellierFrance
  2. 2.INSERM Unit 101ToulouseFrance
  3. 3.University of MilanMilanItaly

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