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Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

  • Book
  • © 1993

Overview

Editors:
  1. Michail V. Sitkovsky

    1. Laboratory of Immunology, Biochemistry and Immunopharmacology Unit, NIH-NIAID, Bethesda, USA

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  2. Pierre A. Henkart

    1. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (60 chapters)

  2. Granule Proteases

    1. Front Matter

      Pages 235-235
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    2. Subtractive and Differential Molecular Biology Approaches to Molecules Preferentially Expressed in Cytotoxic and Other T Cells

      • Eric Rouvier, Pierre Golstein
      Pages 237-250

    3. Structure and Possible Functions of Lymphocyte Granzymes

      • Patrick Haddad, Dieter E. Jenne, Olivier Krähenbühl, Jürg Tschopp
      Pages 251-262

    4. The Role of Granzyme A in Cytotoxic Lymphocyte-Mediated Lysis

      • Mark S. Pasternack
      Pages 263-272

    5. The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo

      • Gillian M. Griffiths, Susan Alpert, R. Jane Hershberger, Lishan Su, Irving L. Weissman
      Pages 273-277

    6. Molecular Analysis and Possible Pleiotropic Function(s) of the T Cell-Specific Serine Proteinase-1 (TSP-1)

      • Markus M. Simon, Klaus Ebnet, Michael D. Kramer
      Pages 278-294

    7. Serine Protease Control of Lymphocyte-Mediated Cytolysis

      • Dorothy Hudig, N. Janine Allison, Gerald R. Ewoldt, Ruth Gault, Dale Netski, Timothy M. Pickett et al.
      Pages 295-304

  3. Alternative Mechanisms of Cytolysis

    1. Front Matter

      Pages 305-305
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    2. Possible Role of Extracellular ATP in Cell-Cell Interactions Leading to CTL-Mediated Cytotoxicity

      • Frank Redegeld, Antonio Filippini, Guido Trenn, Michail V. Sitkovsky
      Pages 307-313

    3. Cell-Permeabilizing Properties of Extracellular ATP in Relation to Lymphocyte-Mediated Cytotoxicity

      • Francesco Di Virgilio, Paola Zanovello, Dino Collavo
      Pages 314-320

    4. The Role of Free Fatty Acids in CTL-Target Cell Interactions

      • Alan M. Kleinfeld
      Pages 321-328

  4. Biochemical and Immunopharmacological Manipulations of Cytotoxic Cells

    1. Front Matter

      Pages 329-329
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    2. Identification of Protein Kinases and Protein Phosphatases Involved in CTL Effector Functions. “ON” and “OFF” Signaling and Immunopharmacological Implications

      • Hirotaka Sugiyama, Sergey Apasov, Guido Trenn, Frank Redegeld, Michail Sitkovsky
      Pages 331-339

    3. Cytolytic Granules as Targets for Immunosuppressive Therapy: Selective Ablation of CTL by Leucyl-Leucine Methyl Ester

      • Dwain L. Thiele, Peter E. Lipsky
      Pages 340-348
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About this book

Our motivation for putting together this book was the need for a single source reference that could be used as an introduction to cell-mediated cytotoxicity for newcomers to this field, such as students and fellows beginning work in our laboratories. At present no such book is available, and we felt that it would be useful as a teaching tool and as a way of conveying our enthusiasm about recent progress in the cytotoxicity field to our colleagues in allied areas. It was with some hesitation that we approached our colleagues with the proposal for this book, and we were pleased to find them very supportive of the idea and willing to participate. We thought it important to broaden the scope of the book to include historical, molecular, cell biological, and clinical aspects of cell-mediated cytotoxicity. To our knowledge this is the first book on cell-mediated cytotoxicity with such a broad scope. Historically, studies on cellular cytotoxicity were part of cellular immunology from its origin. One development of tremendous import was the advent of the 51 Cr assay, which allowed this arm of the immune response to be measured easily and quantitatively. Thus, a readout of this effector pathway is available within a few hours; other immune effector functions can take days or even longer to assay, and the assays are often less quantitative.

Editors and Affiliations

  • Laboratory of Immunology, Biochemistry and Immunopharmacology Unit, NIH-NIAID, Bethesda, USA

    Michail V. Sitkovsky

  • Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA

    Pierre A. Henkart

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