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Red Blood Cell Aging

  • Book
  • © 1991

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Editors:
  1. Mauro Magnani

    1. University of Urbino, Urbino, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Antonio Flora

    1. University of Genoa, Genoa, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 307)

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Table of contents (33 chapters)

  1. Protein Modifications

    1. Role of Hemoglobin Denaturation and Band 3 Clustering in Initiating Red Cell Removal

      • Philip S. Low
      Pages 173-183

    2. A Potential, Intracellular Trigger for Removal of Senescent Erythrocyte: Hemoglobin with Methionine Beta (55) D6 Oxidized to the Sulfoxide Derivative

      • Gino Amiconi, Alberto Bertollini, Rosa Maria Matarese, Donatella Barra
      Pages 185-190

    3. Ubiquitin-Mediated Processes in Erythroid Cell Maturation

      • Arthur L. Haas
      Pages 191-205

    4. Acylphosphatase and Calcium Transport Across Erythrocyte Membrane

      • Chiara Nediani, Gianfranco Liguri, Niccolò Taddei, Elena Marchetti, Giampietro Ramponi, Paolo Nassi
      Pages 207-215

    5. Free Radicals Promote “In Vitro” a Different Intracellular Decay of Rabbit Reticulocyte and Erythrocyte Glycolytic Enzymes

      • Vilberto Stocchi, Beatrice Biagiarelli, Linda Masat, Francesco Palma, Fulvio Palma, Giovanni Piccoli et al.
      Pages 217-223

  2. Enzymology

    1. Front Matter

      Pages 225-225
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    2. Clinical Utility of Fractionating Erythrocytes into “Percoll” Density Gradients

      • Andrea Mosca, Renata Paleari, Annalisa Modenese, Silvano Rossini, Rosalia Parma, Cristina Rocco et al.
      Pages 227-238

    3. The Role of Red Cell Aging in the Diagnosis of Glycolytic Enzyme Defects

      • Gerard E. J. Staal, Gert Rijksen
      Pages 239-249

    4. Molecular Characterization of Plasma Membrane Calcium Pump Isoforms

      • Emanuel E. Strehler, Roger Heim, Ernesto Carafoli
      Pages 251-261

    5. Human Erythrocyte D-Aspartyl/L-Isoaspartyl Methyltransferases: Enzymes that Recognize Age-Damaged Proteins

      • Diego Ingrosso, Steven Clarke
      Pages 263-276

    6. The Isoenzymes of Mammalian Hexokinase: Tissue Specificity and In Vivo Decline

      • Koko Murakami, Sergio Piomelli
      Pages 277-284

    7. Phagocytosis of Phenylhydrazine Oxidized and G-6-PD Deficient Red Blood Cells: The Role of Sugars and Cell-Bound Immunoglobulins

      • Sara Horn, Nava Bashan, Shimon Moses, Jacob Gopas
      Pages 285-300

  3. The Senescent Red Cell and its Removal

    1. Front Matter

      Pages 301-301
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    2. Molecular Mapping of the Active Site of an Aging Antigen

      • Marguerite M. B. Kay, John J. Marchalonis
      Pages 303-316

    3. Recognition Signals for Phagocytic Removal of Favic Malaria-Infected and Sickled Erythrocytes

      • Paolo Arese, Franco Turrini, Federico Bussolino, Hans U. Lutz, Danny Chiu, Lynn Zuo et al.
      Pages 317-327

    4. Inhibition by Carbohydrates and Monoclonal Anticomplement Receptor Type 1, on Interactions between Senescent Human Red Blood Cells and Monocytic Macrophagic Cells

      • Liliane Gattegno, Dominique Bladier, Jenny Vaysse, Line Saffar
      Pages 329-337

    5. In Vitro Sequestration of Erythrocytes from Hosts of Various Ages

      • Harriet Gershon, Edwar Sheiban
      Pages 339-350

    6. A New Monoclonal Antibody to an Age Sensitive Band 3 Transmembrane Segment

      • Lucietta Ferroni, Anna Giuliani, Stefano Marini, Patrizia Caprari, Anna Maria Salvati, Saverio C. Condò et al.
      Pages 351-356

    7. Characterization of Antibody that Binds In Vivo to Normal Human Red Blood Cells

      • Margaret R. Clark, Martin P. Sorette
      Pages 357-365

    8. Opsonic Potential of C3b-Anti-Band 3 Complexes when Generated on Senescent and Oxidatively Stressed Red Cells or in Fluid Phase

      • Hans U. Lutz, Pia Stammler, Daniel Kock, Ronald P. Taylor
      Pages 367-376
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Keywords

About this book

The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.

Editors and Affiliations

  • University of Urbino, Urbino, Italy

    Mauro Magnani

  • University of Genoa, Genoa, Italy

    Antonio Flora

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