© 1991

Red Blood Cell Aging

  • Mauro Magnani
  • Antonio De Flora

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 307)

Table of contents

  1. Front Matter
    Pages i-x
  2. Reticulocyte Maturation

    1. Front Matter
      Pages 1-1
    2. David R. Thorburn, Ernest Beutler
      Pages 15-27
    3. Mauro Magnani, Luigia Rossi, Marzia Bianchi, Giordano Serafini, Vilberto Stocchi
      Pages 29-35
    4. Maria D. Cappellini, Stefania Villa, Alessandro Gaviraghi, Franco Martinez di Montemuros, Dario Tavazzi, Daniela Panzeri et al.
      Pages 37-43
  3. Membranes

    1. Front Matter
      Pages 45-45
    2. J. Clive Ellory, Andrew C. Hall, Susan A. Ody, Carlos E. Poli de Figueiredos, Susan Chalder, John Stuart
      Pages 47-57
    3. Augusta Brovelli, Maria A. Castellana, Giampaolo Minetti, Giampiero Piccinini, Claudio Seppi, Maria R. De Renzis et al.
      Pages 59-73
    4. Bruno Giardina, Roberto Scatena, Maria E. Clementi, Maria T. Ramacci, Franco Maccari, Loredana Cerroni et al.
      Pages 75-84
    5. Laura Mazzanti, Rosa A. Rabini, Roberto Staffolani, Emanuela Faloia, Roberto De Pirro, Armanda Pugnaloni et al.
      Pages 85-89
  4. Metabolism

    1. Front Matter
      Pages 91-91
    2. George L. Dale, Robert B. Daniels, Joshua Beckman, Shannon L. Norenberg
      Pages 93-103
    3. Michele Samaja, Ermanna Rovida, Roberto Motterlini, Massimo Tarantola
      Pages 115-123
    4. William N. Valentine, Donald E. Paglia
      Pages 125-137
    5. Vanna Micheli, Silvia Sestini, Marina Rocchigiani, Monica Pescaglini, Carlo Ricci
      Pages 139-146
  5. Protein Modifications

    1. Front Matter
      Pages 147-147
    2. Patrizia Galletti, Caterina Manna, Diego Ingrosso, Patrizia Iardino, Vincenzo Zappia
      Pages 149-160
    3. Antonio De Flora, Gianluca Damonte, Adina Sdraffa, Luisa Franco, Umberto Benatti
      Pages 161-171

About this book


The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.


Mammalia biochemistry metabolism physiology proteins

Editors and affiliations

  • Mauro Magnani
    • 1
  • Antonio De Flora
    • 2
  1. 1.University of UrbinoUrbinoItaly
  2. 2.University of GenoaGenoaItaly

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology