© 1991

Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

  • Mohan K. Raizada
  • Derek LeRoith

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Insulin-Like Growth Factors I and II

    1. J. S. Sussenbach, P. H. Steenbergh, E. Jansen, P. Holthuizen, D. Meinsma, M. A. van Dijk et al.
      Pages 1-14
    2. P. Kay Lund, Eileen C. Hoyt, Judson J. Van Wyk
      Pages 15-21
    3. Steen Gammeltoft, Jan Christiansen, Finn C. Nielsen, Sten Verland
      Pages 31-44
    4. James F. Perdue, Linda K. Gowan, W. Robert Hudgins, Joan Scheuermann, Beverly Foster, Sharron Northcutt Brown
      Pages 45-56
    5. K. A. Magri, D. Z. Ewton, J. R. Florini
      Pages 57-76
    6. Raffaele Zarrilli, Vittorio Colantuoni, Raffaella Faraonio, Stefano Casola, Elena Rossi, Carmelo B. Bruni
      Pages 77-83
    7. Thomas J. Merimee, Suzanne Quinn, Betty Russell, William Riley
      Pages 85-96
    8. Hans-Peter Guler, Katharina Wettstein, Werner Schurr, Jurgen Zapf, E. Rudolf Froesch
      Pages 97-104
    9. Naomi Hizuka, Kazue Takano, Kumiko Asakawa, Izumi Fukuda, Izumi Sukegawa, Kazuo Shizume et al.
      Pages 105-112
  3. Insulin-Like Growth Factor Binding Proteins

    1. Robert C. Baxter, Janet L. Martin
      Pages 125-135
    2. Matthew M. Rechler, Alexandra L. Brown, Guck T. Ooi, Craig C. Orlowski, Lucy Y.-H. Tseng, Yvonne W.-H. Yang
      Pages 137-148
    3. Liam J. Murphy, Jiangming Luo, Charita Seneviratne
      Pages 149-160
    4. Michel Binoux, Monireh Roghani, Paul Hossenlopp, Odile Whitechurch
      Pages 161-170
    5. Anthony F. Philipps, Jean M. Wilson, Radhakrishna Rao, David M. McCracken, Otakar Koldovsky
      Pages 179-186
  4. Receptors for Insulin, IGF-I and II

    1. Barry J. Goldstein, Alana L. Dudley
      Pages 187-195
    2. Simeon I. Taylor, Domenico Accili, Alessandro Cama, Hiroko Kadowaki, Takashi Kadowaki, Eiichi Imano et al.
      Pages 197-213

About this book


This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.


biology cartilage growth molecular biology physiology proteoglycan synthesis synthesis tissue

Editors and affiliations

  • Mohan K. Raizada
    • 1
  • Derek LeRoith
    • 2
  1. 1.University of FloridaGainesvilleUSA
  2. 2.National Institutes of HealthBethesdaUSA

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