Biological Reactive Intermediates IV

Molecular and Cellular Effects and Their Impact on Human Health

  • Charlotte M. Witmer
  • Robert R. Snyder
  • David J. Jollow
  • George F. Kalf
  • James J. Kocsis
  • I. Glenn Sipes

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Sessions I – VI

    1. F. Peter Guengerich, Tsutomu Shimada, Arnaud Bondon, Timothy L. Macdonald
      Pages 1-11
    2. Franz Oesch, Ingolf Gath, Takashi Igarashi, Hansruedi Glatt, Barbara Oesch-Bartlomowicz, Helmut Thomas
      Pages 25-39
    3. V. Ullrich, M. Schatz, F. Meisch
      Pages 79-86
    4. James A. Thomas, Eun-Mi Park, Yuh-Cherng Chai, Robert Brooks, Kazuhito Rokutan, Richard B. Johnston Jr.
      Pages 95-103
    5. James R. Halpert, Jeffrey C. Stevens
      Pages 105-109
    6. Lance R. Pohl, David Thomassen, Neil R. Pumford, Lynn E. Butler, Hiroko Satoh, Victor J. Ferrans et al.
      Pages 111-120
    7. Regina M. Santella, Yu Jing Zhang, Tie Lan Young, Byung Mu Lee, Xiao Qing Lu
      Pages 165-181
    8. Bradley D. Preston, Rupa Doshi
      Pages 193-209
    9. Bernard Strauss, Edith Turkington, Jhy Wang, Daphna Sagher
      Pages 211-223
    10. Marshall W. Anderson, Ming You, Steven H. Reynolds
      Pages 235-243
  3. Short Communications

    1. Martin L. Appleton, Douglas N. Larson, Gary L. Skiles, William K. Nichols, Garold S. Yost
      Pages 245-248
    2. Timothy P. Bradshaw, D. C. McMillan, R. K. Crouch, D. J. Jollow
      Pages 253-255
    3. Thomas A. Chepiga, Chung S. Yang, Robert Snyder
      Pages 261-265
    4. P. G. Gervasi, P. Puccini, V. Longo, A. Lippi
      Pages 285-287
    5. Hartmut Jaeschke, Arthur E. Benzick, Charles V. Smith, Jerry R. Mitchell
      Pages 295-298
    6. James P. Kehrer, Youngja Park
      Pages 299-304
    7. Qiang Ma, Regina Wang, Anthony Y. H. Lu, Chung S. Yang
      Pages 323-327
    8. Maurizio Manno, Michela Rezzadore, Stefano Cazzaro
      Pages 329-332
    9. David C. McMillan, Timothy P. Bradshaw, JoEllyn M. McMillan, Jack A. Hinson, David J. Jollow
      Pages 343-345
    10. K. J. Netter, B. Hahnemann, S. A. Mangoura, F. Feil, M. Tegtmeier, R. T. Mayer et al.
      Pages 353-357
    11. Roger P. Smith, Dean E. Wilcox, Harriet Kruszyna, Robert Kruszyna
      Pages 365-369
    12. Anthony J. Streeter, Raymond W. Nims, Pamela R. Sheffels, Larry K. Keefer
      Pages 371-375

About this book


The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co­ chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co­ chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.


Calcium DNA Oxidation alcohol cancer cell culture chemotherapy cytokine enzymes kidney metabolism mutation oncogene research toxicology

Editors and affiliations

  • Charlotte M. Witmer
    • 1
  • Robert R. Snyder
    • 1
  • David J. Jollow
    • 2
  • George F. Kalf
    • 3
  • James J. Kocsis
    • 3
  • I. Glenn Sipes
    • 4
  1. 1.Rutgers UniversityPiscatawayUSA
  2. 2.Medical University of South CarolinaCharlestonUSA
  3. 3.Thomas Jefferson UniversityPhiladelphiaUSA
  4. 4.University of ArizonaTucsonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5879-4
  • Online ISBN 978-1-4684-5877-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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