Immunobiology and Prophylaxis of Human Herpesvirus Infections

1. Herpes Simplex Virus Latency

   1. Transcripts Associated with Herpes Simplex Virus Latency

      • Jack G. Stevens

      Pages 199-204

   2. Pathogenesis and Latency of Herpes Simplex Virus Type 1 (HSV-1): An Ophthalmologist’s View of the Eye as a Model for the Study of the Virus-Host Relationship

      • Y. Jerold Gordon

      Pages 205-209

   3. Mechanisms of Restriction of Viral Gene Expression during Herpes Simplex Virus Latency

      • Amy E. Sears

      Pages 211-217

2. Diagnostics

   1. Detection of a Highly Conserved Region of Herpesviridae DNA by In Vitro Enzymatic Amplification: Application to the Detection of a New Human Herpesvirus

      • Steven Wolinsky, Jan Andersson, Anne Rowley

      Pages 219-229

   2. Prevalence of Specific Antibodies to Herpes Simplex Virus Type 2 as Revealed by an Enzyme-linked Immunoassay and Western Blot Analysis

      • Karen V. Spiezia, Bruce J. Dille, Isa K. Mushahwar, Lemma Kifle, Greg F. Okasinski

      Pages 231-242

3. Chemotherapy of Herpesvirus Infections

   1. Acyclovir: The Past Ten Years

      • Richard J. Whitley, Mark Middlebrooks, John W. Gnann Jr.

      Pages 243-253

   2. Brovavir: Its Antiherpesviral Activity and Mode of Action

      • Haruhiko Machida

      Pages 255-265

   3. A Double-Blind Clinical Study in Patients with Herpes Zoster to Establish YN-72 (Brovavir) Dose

      • Michihito Niimura

      Pages 267-275

   4. (S)-1-(3-Hydroxy-2-(phosphonylmethoxy)propyl)cytosine (HPMPC): A Potent Antiherpesvirus Agent

      • Joanne J. Bronson, Louis M. Ferrara, Michael J. M. Hitchcock, Hsu-Tso Ho, Kathleen L. Woods, Ismail Ghazzouli et al.

      Pages 277-283

4. Conclusions

   1. Whither Herpesviruses

      • Bernard Roizman

      Pages 285-291

5. Back Matter

   Pages 293-296

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No one whose opinion deserves a moment's consideration can doubt that most of the great positive evils of the world are in themselves removable, and will, if human affairs continue to improve, be in the end reduced to narrow limits. J. S. Mill, Utilitarianism, II, 1863 Mill was not writing about herpesviruses, but had he known them as we do, he would have included them among the great positive evils of the world. They cause disease and premature death, and are very costly to our society. There is no loftier aim than to cure or prevent human infections with these viruses. The objective of much of the current research on herpesviruses is directed toward an understanding of the molecular mechanisms involved in initiation of infection, establish­ ment and termination of latent state, virus multiplication, and the destruction of cells which ultimately is the basis of the diseases caused by these viruses. At no time during the past 80 years, since members of the herpesvirus family were first discovered, has there been so much progress in our understanding of the biology of these viruses as in the past few years. Along with the development of a greater understanding of the molecular biol­ ogy of the well-known herpesviruses we have witnessed the isolation of new human herpes­ viruses.

• development
• immunobiology
• infection
• infections
• virus
• infectious diseases

• Eli Lilly and Company, Indianapolis, USA

  Carlos Lopez

• Kyushu University, Fukuoka, Japan

  Ryoichi Mori

• The University of Chicago, Chicago, USA

  Bernard Roizman

• University of Alabama at Birmingham, Birmingham, USA

  Richard J. Whitley

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