Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

1. Amyloid

   1. Light and Electron Microscopic Observations of Diffuse Plaque and Its Related Conditions

      • Kenji Ikeda, Chie Haga, Kenji Kosaka, Shinsaku Oyanagi

      Pages 95-99

   2. β-Amyloid Plaques and Dementia: An Immunohistochemical Study

      • Shigeki Kuzuhara, Yasuo Ihara, Hiroyuki Shimada, Yasuo Toyokura

      Pages 101-105

   3. Diagnosis of Cerebral Amyloid Angiopathy with Cerebral Hemorrhage by Enzyme-Linked Immunosorbent Assay (ELISA) of Cystatin C in Cerebrospinal Fluid

      • Koichi Shimode, Shigeyoshi Fujihara, Morihiko Nakamura, Shotai Kobayashi, Tokugoro Tsunematsu

      Pages 107-110

   4. Cystatin C (γ-Trace) and β-Protein Coexist in the Cerebral Amyloid Angiopathy Causing Cerebral Hemorrhage and Consequential Vascular Dementia

      • Shigeyoshi Fujihara, Koichi Shimode, Morihiko Nakamura, Shotai Kobayashi, Tokugoro Tsunematsu, Astridur Palsdottir et al.

      Pages 111-115

2. The Neuronal Breakdown-1 (Alzheimer)

   1. The Regulation of Cytoskeletal Elements in Differentiating Human Neuroblastoma and Rat Pheochromocytoma PC-12 Cells

      • Uriel Z. Littauer, Joachim Kirsch, Irith Ginzburg

      Pages 117-122

   2. Some Findings on Intermediate Filaments in Alzheimer’s Disease

      • Tsuyoshi Nishimura, Masatoshi Takeda, Kazuko Nakamura, Junya Tanaka, Yu Nakamura, Takashi Kudo

      Pages 123-127

   3. A Unifying Hypothesis on the Etiology of Alzheimer’s Disease

      • Zaven S. Khachaturian

      Pages 129-132

   4. Abnormal Phospholipid Metabolism in Neurodegenerative Diseases: Elevations in Glycerophosphocholine and Glycerophospho-Ethanolamine Levels in Brain of Alzheimer’s Disease But Not in Down Syndrome Patients

      • Jan Krzysztof Blusztajn, Ignacio Lopez Gonzalez-Coviella, Mary Logue, John H. Growdon, Richard J. Wurtman

      Pages 133-138

   5. Alterations in Catecholamine and Peptide Neurons in the Locus Coeruleus in Dementias of Alzheimer’s and Parkinson’s Disease

      • Victoria Chan-Palay

      Pages 139-145

   6. The Role of Neuronal Membranes Deterioration in The Pathogenesis of Alzheimer’s Disease: An Ultrastructural Perspective

      • Carlo Bertoni-Freddari, Patrizia Fattoretti, Tiziana Casoli, William Meier-Ruge, Jurg Ulrich

      Pages 147-152

   7. Experimental Synaptic Degeneration as a Model for the Pathogenesis of Alzheimer’s Disease: Monoclonal Antibodies and a Protein Kinase Inhibitor Block Synapse Formation and Maintenance Between Cultured CNS Neurons

      • Yoichiro Kuroda, Kazuo Kobayashi, Kazuyo Muramoto, Akihiko Ogura, Yoshihisa Kudo, Satoshi Nakanishi

      Pages 153-156

   8. Pathobiochemical Aspects of Parkinson’s Disease and Dementia of Alzheimer Type

      • Peter Riederer, Wieland Gsell, Gunther Moli, Emin Sofic, Heinz Reichmann, Alex Freyberger et al.

      Pages 157-163

   9. Characterization of Alzheimer Neurofibrillary Tangle (NFT) Epitopes and the Binding Site for the Regulatory Subunit (RII) of cAMP-Dependent Protein Kinase II in Human Microtubule-Associated Protein 2 (MAP-2)

      • Bridget Shafit-Zagardo, Marilyn Dammerman, Heidi Rubino, Shu-Hui Yen, Jack Erlichman

      Pages 165-168

   10. Identification and Characterization of Modified Forms of Tau in Brains with Alzheimer’s Disease

       • Shu-Hui Yen, Wan-Kyng Liu, Hanna Ksiezak-Reding

       Pages 169-172

   11. Phosphorylation of Tau Protein with a Novel Tau Protein Kinase Forming Paired Helical Filament Epitopes on Tau

       • Koichi Ishiguro, Kazuki Sato, Akira Omori, Kayoko Tomizawa, Tsuneko Uchida, Kazutomo Imahori

       Pages 173-176

   12. Aberration of Vimentin Array in Fibroblast from Familial Alzheimer’s Disease

       • Masatoshi Takeda, Takashi Kudo, Yu Nakamura, Masako Tanaka, Kunitoshi Tada, Tsuyoshi Nishimura

       Pages 177-181

   13. Regional Phospholipid Profile of Alzheimer’s Brain

       • Tsutomu Nakada, Ingrid L. Kwee, Nobuyuki Suzuki, William G. Ellis

       Pages 183-186

   14. Age-Related Changes in the Rate and Composition of the Slow Axonal Transport

       • Yoshiaki Komiya, Tomoko Tashiro

       Pages 187-190

   15. Astroglial Gene Expression in the Hippocampus Following Partial Deafferentation in the Rat and in Alzheimer’s Disease

       • Judes Poirier, Mark Hess, Patrick C. May, Giulio Pasinetti, Caleb E. Finch

       Pages 191-194

   16. Blood-Brain Barrier Disturbance in Patients with Alzheimer’s Disease is Related to Vascular Factors

       • K. Blennow, A. Wallin, P. Fredman, I. Karlsson, C. G. Gottfries, L. Svennerholm

       Pages 195-198

This two-volume work contains the full text of the oral and poster presentations and the general discussion at the round table discussion of the Second International Conference on Alzheimer's and Parkinson's Diseases: Basic and Therapeutic Strategies, held at the Kyoto Park Hotel in Kyoto, Japan, on November 6-10, 1989. The First Conference was held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. The record of this First Conference was published by Plenum Press in 1986 as Volume 29 in Advances in Behavioral Biology, under the title "Alzheimer's and Parkinson's Diseases: Strategies for Research and Development." We are happy that the comprehensive texts of the oral and poster presentations of the Second Conference could again be published within the framework of this series. Since the First Conference in 1985, rapid progress has been made in both basic and 'therapeutic aspects of these diseases. About 700 scientists from allover the world participated in the Second Conference, and 300 papers were presented in oral and poster sessions. Many people and organizations have helped to organize this multi­ disciplinary international conference and hence have contributed to the scientific quality of these two volumes. We thank the members of the organizing committee, the organizations that provided financial support, and the contributing scientists for their enthusiastic participation. These two volumes follow the same publishing philosophy as the volume derived from the First Conference. They span a broad spectrum of topics and bridge preclinical and clinical concepts related to these diseases.

• Alzheimer's disease
• Alzheimer´s disease
• Parkinson
• anatomy
• brain
• brainstem
• cortex
• dementia
• neurobiology
• neurons
• neuropeptides
• neuropharmacology
• pharmacology
• physiology
• research

• Nagoya University School of Medicine, Nagoya, Japan

  Toshiharu Nagatsu

• Israel Institute for Biological Research, Ness-Ziona, Israel

  Abraham Fisher

• Jichi Medical School, Tochigi, Japan

  Mitsuo Yoshida

Policies and ethics