© 1990

Tobacco Smoking and Atherosclerosis

Pathogenesis and Cellular Mechanisms

  • John N. Diana

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)

Table of contents

  1. Front Matter
    Pages i-x
  2. Tobacco Smoking and Atherosclerosis: Overview

  3. Epidemiologic Studies Linking Smoking and Atherosclerosis

    1. Henry C. McGill Jr.
      Pages 9-16
    2. Dwayne Reed, Ellen Marcus, Takuji Hayashi
      Pages 17-25
    3. Grethe S. Tell, George Howard, Gregory W. Evans, Michael L. Smith, William M. McKinney, James F. Toole
      Pages 39-49
  4. Effect of Cigarette Smoking on Vascular Endothelial Cells

  5. Effect of Cigarette Smoking on Platelets, Vascular Tissue and Eicosanoids

    1. J. Y. Jeremy, D. P. Mikhailidis
      Pages 135-146
    2. Gordon R. Campbell, Julie H. Campbell
      Pages 147-159
    3. Donald D. Heistad, J. Antonio Lopez, Mark L. Armstrong
      Pages 173-180
    4. Paul D. Stein, Jan Rival, Jeanne M. Riddle
      Pages 181-187
    5. John J. Murray, Jacek Nowak, John A. Oates, Garret A. FitzGerald
      Pages 189-198

About this book


Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the epidemiologic correlation between cigarette smoking and the development of atherosclerosis needs further critical studies. It is known that individuals who do not smoke cigarettes develop athero­ sclerosis and it is also known that in people who smoke but have normal or low blood cholesterol/lipoprotein levels, the incidence of development of atherosclerosis is no different from that which is found in a non­ smoking population. Answers which explain such observations must address fundamental biological mechanisms. Toward this end, the purpose of this volume is to assemble, in a single publication, information which will address the questions; what basic cellular and/or molecular mechanisms are associated with the development of atherosclerosis and how does cigarette smoking influence such mechanisms to initiate or exacerbate the atherosclerotic process? Clearly, the development of atherosclerosis is a complex, multifactorial biological event.


Lipoprotein atherosclerosis cardiovascular protein vascular disease

Editors and affiliations

  • John N. Diana
    • 1
  1. 1.Tobacco and Health Research InstituteUniversity of KentuckyLexingtonUSA

Bibliographic information

  • Book Title Tobacco Smoking and Atherosclerosis
  • Book Subtitle Pathogenesis and Cellular Mechanisms
  • Editors John N. Diana
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-43668-0
  • Softcover ISBN 978-1-4684-5831-2
  • eBook ISBN 978-1-4684-5829-9
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages , 404
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
    Biochemistry, general
  • Buy this book on publisher's site
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