Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

  • Derek LeRoith
  • Mohan K. Raizada

Table of contents

  1. Front Matter
    Pages N2-xii
  2. General Aspects of Insulin-Like Growth Factor Physiology

    1. William H. Daughaday
      Pages 1-4
    2. Michael Berelowitz
      Pages 25-37
    3. Ron G. Rosenfeld, Ian Ocrant, Karen L. Valentino, Andrew R. Hoffman
      Pages 39-56
    4. L. S. Phillips, S. Goldstein, J. D. Klein
      Pages 81-95
  3. Molecular Biology of Insulin-Like Growth Factors

    1. Charles T. Roberts Jr., William L. Lowe Jr., Derek LeRoith
      Pages 107-116
    2. P. Rotwein, D. DeVol, P. Lajara, P. Bechtel, M. Hammerman
      Pages 117-124
    3. Hisanori Kato, Yutaka Miura, Asako Okoshi, Tsutomu Umezawa, Shin-Ichiro Takahashi, Tadashi Noguchi
      Pages 125-128
    4. Thomas R. Johnson, Joseph Ilan
      Pages 129-139
    5. Eli Y. Adashi, Carol E. Resnick, Eleuterio R. Hernandez, Marjorie E. Svoboda, Judson J. Van Wyk
      Pages 141-151
    6. Liam J. Murphy, Henry G. Friesen
      Pages 153-168
    7. Keith D. Boehm, Michael F. Kelley, Judith Ilan
      Pages 179-193
    8. Frank A. Simmen, Rosalia C. M. Simmen, L. Roxanne Letcher, Douglas A. Schober, Yong Ko
      Pages 195-208
    9. Teresa L. Wood, Michael Berelowitz, Jeffrey F. McKelvy
      Pages 209-217
    10. Kenneth M. Rosen, Bruce M. Wentworth, Edward D. Lamperti, Stanislaus Kinota, Richard O’Brien, Nadia Rosenthal et al.
      Pages 219-229
    11. S. Devaskar, H. F. Sadiq
      Pages 231-235
    12. Douglas Yee, Kevin J. Cullen, Soonmyoung Paik, Marc E. Lippman, Neal Rosen
      Pages 237-245
    13. Gabriele Jaques, Klaus Havemann
      Pages 247-260
  4. Structural and Functional Relationships of the Insulin-Like Growth Factor Receptors

    1. Joyce F. Haskell, Linda E. Haws, Alberta Davis, Richard Hunt
      Pages 297-308
    2. Cary Moxham, Vincent Duronio, Steven Jacobs
      Pages 309-314
    3. Laura M. Mudd, Mohan K. Raizada
      Pages 315-325
    4. Peter Nissley, Wieland Kiess, Mark Sklar
      Pages 359-367
  5. Cellular Actions of Insulin-Like Growth Factors

    1. Matthew M. Rechler, Alexandra L. Brown, Craig C. Orlowski, Yvonne W.-H. Yang, Joyce A. Romanus, Lorenzo Chiariotti et al.
      Pages 395-402
    2. Dianne Figlewicz Lattemann, Michael G. King, Patricia Szot, Denis G. Baskin
      Pages 427-434
    3. Gary L. Engelmann, Joyce F. Haskell, Keith D. Boehm
      Pages 443-458
    4. Ernesto Canalis, Michael Centrella, Thomas L. McCarthy
      Pages 459-466
    5. Mary K. Dahmer, Robert L. Perlman
      Pages 467-472
  6. Back Matter
    Pages 495-511

About this book


An essential element in the development and functional integrity of all organisms is intercellular communication. This is achieved by the secretion of soluble messenger molecules which subsequently interact with receptor-effector pathways in the responsive cells. Hormones are traditionally defined as chemical messengers synthesized by endocrine glands. Unlike hormones produced by endocrine glands, growth factors are hormone-related substances produced by many tissues and play an important role in controlling growth and development. While the exact physiological roles of growth factors have yet to be elucidated, they play important roles in the regulation of cellular proliferation and/or differentiation during ontogenesis, growth and differentiation. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes. Furthermore, there are distinct families of growth factors based either on structural or functional similarities.


biology cells central nervous system physiology regulation retina tissue

Editors and affiliations

  • Derek LeRoith
    • 1
  • Mohan K. Raizada
    • 2
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.University of FloridaGainesvilleUSA

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