Purine and Pyrimidine Metabolism in Man VI

Part A: Clinical and Molecular Biology

  • Kiyonobu Mikanagi
  • Kusuki Nishioka
  • William N. Kelley

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Table of contents

  1. Renal Handling of Oxypurines

    1. Takashi Dan, Hiroshi Koga, Etsuro Onuma, Haruko Tanaka, Haruhiko Sato, Bunya Aoki
      Pages 301-308
    2. Kiyoko Kaneko, Shin Fujimori, Takaaki Kanbayashi, Ieo Akaoka
      Pages 309-315
  2. Nucleotide Catabolism

    1. M. F. Vincent, G. Van den Berghe, H. G. Hers
      Pages 317-323
    2. Alfredo D. Michán, Juan G. Puig, Pascual F. Crespo, Francisco L. Macías, Antonio A. González, Julio Ortiz
      Pages 325-331
    3. Felícitas A. Mateos, Pablo F. Gómez, Juan G. Puig, Manuel L. Jiménez, Teresa H. Ramos, José G. Mantilla
      Pages 333-338
    4. Felícitas A. Mateos, Juan G. Puig, Teresa H. Ramos, Ramón H. Carranza, María E. Miranda, Rafael C. Gasalla
      Pages 345-352
    5. Roger A. Lewis, Laura Link, Wilbert Chen
      Pages 353-357
    6. Esther Zoref-Shani, Genia Kessler-Icekson, Oded Sperling
      Pages 359-362
  3. Muscle and Purine Metabolsim

    1. Naoko Hara, Ikuo Mineo, Yuya Yamada, Masanori Kawachi, Hiroaki Kiyokawa, Tomoyuki Yamasaki et al.
      Pages 363-367
    2. Masashi Ogasawara, Tetsuya Seino, Shinji Hadano, Akira Ito, Hiroshi Goto, Mitsuo Itakura
      Pages 369-374
    3. Takao Shimizu, Norio Kono, Hiroaki Kiyokawa, Yuya Yamada, Naoko Hara, Ikuo Mineo et al.
      Pages 375-379
    4. Naoko Hara, Ikuo Mineo, Norio Kono, Hiroaki Kiyokawa, Masanori Kawachi, Yuya Yamada et al.
      Pages 381-386
  4. Purine Metabolism in Human Tissue

    1. Giovanni Ronca, Angela Conte, Simonetta Ronca-Testoni, Riccardo Zucchi, Rosa Poddighe, Rita Mariotti et al.
      Pages 387-391
    2. Robert L. Wortmann, Judith A. Veum, John W. Rachow
      Pages 393-398
    3. Kari O. Raivio, Kim Vettenranta
      Pages 399-406
    4. Enrico Marinello, Daniela Vannoni, Brunetta Porcelli, Egidio Dispensa
      Pages 407-410
    5. A. Giacomello, C. Salerno, P. Cardelli, M. C. Santulli, A. Rossi, R. Strom
      Pages 411-415
    6. Tadashi Ikegami, Yutaka Natsumeda, George Weber
      Pages 417-421
    7. Hiroshi Tsutani, Teruo Yoshimura, Michihiko Uchida, Kenichi Kamiya, Takanori Ueda, Toru Nakamura
      Pages 423-426
  5. Anti-Cancer Purine and Pyrimidine Analogs Clinical Aspects

    1. Dennis A. Carson, Lawrence D. Piro, D. Bruce Wasson, Carlos J. Carrera, Ernest Beutler
      Pages 427-431
    2. Yolanda M. T. Marijnen, Dirk de Korte, Dirk Roos, Albert H. van Gennip
      Pages 433-438
    3. Godefridus J. Peters, Emile J. Laurensse, Cees J. van Groeningen, Sybren Meijer, Herbert M. Pinedo
      Pages 439-445
    4. R. Pieters, D. R. Huismans, A. Leyva, A. J. P. Veerman
      Pages 447-454
    5. Tomoko Hasunuma, Hisashi Yamanaka, Chihiro Terai, Nobuyuki Miyasaka, Naoyuki Kamatani, Kusuki Nishioka et al.
      Pages 455-460
  6. Molecular Genetics of Purine and Pyrimidine Enzymes

    1. Milton W. Taylor, Joo-Hung Park, De-Chu Tang
      Pages 467-473
    2. Howard V. Hershey, Milton W. Taylor
      Pages 475-480
    3. Hiromu Nakajima, Tamio Noguchi, Ikuo Mineo, Tomoyuki Yamasaki, Norio Kono, Takehiko Tanaka et al.
      Pages 485-491
    4. E. G. Chottiner, D. Ginsburg, B. S. Mitchell
      Pages 493-497
    5. Cheng Chi Lee, Xiangwei Wu, C. Thomas Caskey
      Pages 499-505
    6. Masaki Ito, Masamichi Nakamura, Hisamitsu Ogawa, Yasuyuki Takagi
      Pages 507-510
    7. Mariko Suchi, Nobuhiro Harada, Takashi Tsuboi, Kiyofumi Asai, Kazuki Okajima, Yoshiro Wada et al.
      Pages 511-518
    8. Taizo Iizasa, Masanori Taira, Hideaki Shimada, Masamiti Tatibana
      Pages 519-523
    9. Masamiti Tatibana, Masanori Taira, Sumio Ishijima, Kazuko Kita, Hideaki Shimada, Kazumi Yamada et al.
      Pages 525-530
  7. Approaches to the Gene Therapy

  8. Back Matter
    Pages 555-560

About this book


These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.


ATP Colon DNA Glycogen Nucleotide Purine Pyrimidine RNA amino acid enzyme enzymes metabolism mutation protein translation

Editors and affiliations

  • Kiyonobu Mikanagi
    • 1
  • Kusuki Nishioka
    • 2
  • William N. Kelley
    • 3
  1. 1.Mikanagi Gotanda HospitalTokyoJapan
  2. 2.Tokyo Women’s Medical CollegeTokyoJapan
  3. 3.University of Michigan Medical CenterAnn ArborUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5675-2
  • Online ISBN 978-1-4684-5673-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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