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  • Book
  • © 1989

Purine and Pyrimidine Metabolism in Man VI

Part A: Clinical and Molecular Biology

Editors:

  1. Kiyonobu Mikanagi

    1. Mikanagi Gotanda Hospital, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Kusuki Nishioka

    1. Tokyo Women’s Medical College, Tokyo, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. William N. Kelley

    1. University of Michigan Medical Center, Ann Arbor, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 253A)

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Table of contents (89 chapters)

  1. HGPRT Deficiencies and Lesch-Nyhan Syndrome

    1. The Spectrum of HPRT Deficiency: An Update

      • Theodore Page, William L. Nyhan
      Pages 129-133

    2. Lesch-Nyhan Syndrome due to a Single Nucleotide Change in the Hypoxanthine-Guanine Phosphoribosyltransferase Gene (HPRT Yale)

      • Shin Fujimori, Beverly L. Davidson, William N. Kelley, Thomas D. Palella
      Pages 135-138

    3. Structural Consequences of Point Mutations in Nine Human HPRT Variants

      • Beverly L. Davidson, Thomas D. Palella, Shin Fujimori, William N. Kelley
      Pages 139-143

    4. Lesch-Nyhan Syndrome and HPRT Variants: Study of Heterogeneity at the Gene Level

      • Surjit Singh, Ingrid Willers, Karsten Held, Werner Goedde
      Pages 145-150

    5. Characterization of Genomic DNA, mRNA and Enzyme Protein in Cases of HPRT Deficiency

      • R. B. Gordon, D. T. Keough, D. G. Sculley, J. de Jersey, B. T. Emmerson, I. R. Beacham
      Pages 151-154

    6. Is HPRT-like Protein Present in Lesch-Nyhan Patients?

      • D. T. Keough, R. B. Gordon, J. de Jersey, B. T. Emmerson
      Pages 155-158

    8. Hypoxanthine Accumulation and Dopamine Depletion in Lesch-Nyhan Disease

      • Roberta M. Palmour, Timothy W. Heshka, Frank R. Ervin
      Pages 165-172

    9. Hypoxanthine and Xanthine Transport through the Blood-Brain Barrier in Hypoxanthine Phosphoribosyltransferase (HPRT) Deficiency

      • Manuel L. Jiménez, Juan G. Puig, Felícitas A. Mateos, Teresa H. Ramos, Ignacio P. Castroviejo, Julio O. Vázquez
      Pages 173-179

    10. Cerebrospinal Fluid Cyclic Nucleotide Alterations in the Lesch-Nyhan Syndrome

      • N. Lawrence Edwards, Michael V. Johnston, Faye S. Silverstein
      Pages 181-184

    11. Purine Nucleotide Restoration in HPRT- Cells

      • Theodore Page
      Pages 185-188

  2. Gout and Uric Acid

    1. Clinical Aspects of Gouty Patients in Taiwan

      • Ching-Lang Chen, Naoyuki Kamatani, Kusuki Nishioka, Kiyonobu Mikanagi
      Pages 189-195

    2. Can Risk Scores for Vascular Disease in Gout Patients be Improved?

      • Lynda G. Darlington, James T. Scott
      Pages 197-204

    3. A Model of Gout Nephropathy

      • Bryan T. Emmerson, Roy Axelsen, Michael Cross
      Pages 205-209

    4. Hyperuricemia, Gout and Idiopathic Aseptic Necrosis of Bone

      • A. Giacomello, A. Zoppini, M. L. Sorgi, V. Riccieri, C. Salerno
      Pages 211-214

    5. The Solubility of Uric Acid and Monosodium Urate in Urine

      • Toru Shimizu, Mineko Nishikawa, Hiroshi Matsushige
      Pages 215-218

    6. A Role of Interleukin-1 (IL-1) in Crystal-Induced Arthritis

      • Kumiko Hashizume, Minoru Sasano, Makoto Goto, Nobuyuki Miyasaka, Kusuki Nishioka
      Pages 219-224

    7. Is Gout Related to an Alteration of the Uric Acid Protein Binding?

      • Taddeo Anna, Morozzi Gabriella, Marcolongo Roberto
      Pages 225-232

    8. Urate Binding Globulin, Interactions with Immunoglobulins

      • Maria R. Mazzoni, Gino Giannaccini, Fabio Lena, Claudia Martini, Laura Bazzichi, Maria L. Ciompi et al.
      Pages 233-237

    9. Behavior of Oxypurines in Normal Subjects After an 8 Day Purine-Free Diet

      • Enrico Marinello, Brunetta Porcelli, Daniela Vannoni, Anna Taddeo
      Pages 239-242
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About this book

These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.
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Keywords

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Editors and Affiliations

  • Mikanagi Gotanda Hospital, Tokyo, Japan

    Kiyonobu Mikanagi

  • Tokyo Women’s Medical College, Tokyo, Japan

    Kusuki Nishioka

  • University of Michigan Medical Center, Ann Arbor, USA

    William N. Kelley

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Bibliographic Information

  • Book Title: Purine and Pyrimidine Metabolism in Man VI

  • Book Subtitle: Part A: Clinical and Molecular Biology

  • Editors: Kiyonobu Mikanagi, Kusuki Nishioka, William N. Kelley

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5673-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1989

  • Softcover ISBN: 978-1-4684-5675-2Published: 17 April 2013

  • eBook ISBN: 978-1-4684-5673-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 560

  • Topics: Biochemistry, general

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

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