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Progress in Polyamine Research

Novel Biochemical, Pharmacological, and Clinical Aspects

  • Book
  • © 1988

Overview

Editors:
  1. Vincenzo Zappia

    1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

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  2. Anthony E. Pegg

    1. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 250)

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Table of contents (67 chapters)

  1. Metabolism of 5′ -Methylthioadenosine in Normal and Transformed Cells

    1. Physico-Chemical and Immunological Properties of Bovine Liver 5′-Deoxy-5′-Methylthioadenosine Phosphorylase

      • Fulvio Della Ragione, Adriana Oliva, Massimo Fioretti, Gian Luigi Russo, Rosanna Palumbo, Vincenzo Zappia
      Pages 187-197

    2. Exploitation of Methylthioribose Kinase in the Development of Antiprotozoal Drugs

      • John H. Fitchen, Michael K. Riscoe, Adolph J. Ferro
      Pages 199-210

    3. MTA Phosphorylase in Protozoa: A Potential Target for Chemotherapeutic Attack

      • Richard L. Miller, David P. Toorchen
      Pages 211-218

    4. Characterization and Biogenesis of 5′-Methylthioxylofuranosyl Adenine, a New Natural Analog of 5′-Methylthioadenosine

      • Marina Porcelli, Giovanna Cacciapuoti, Guido Cimino, Margherita Gavagnin, Guido Sodano, Vincenzo Zappia
      Pages 219-228

    5. Studies on Human Serum 5′ -Deoxy-5′ -Methylthioadenosine Phosphorylase: Molecular Properties and Clinical Perspectives

      • Gian Luigi Russo, Fulvio Della Ragione, Riccardo Utili, Augusto Andreana, Giuseppe Ruggiero, Vincenzo Zappia
      Pages 229-238

  2. Polyamines in Cell Growth and Differentiation

    1. Front Matter

      Pages 239-239
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    2. Growth-Regulation of the Cellular Levels and Expression of the mRNA Molecules Coding for Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase

      • David R. Morris, Michael W. White
      Pages 241-252

    3. Structure, Amplification and Methylation of Ornithine Decarboxylase Genes in Human Malignant Cells

      • Juhani Jänne, Leena Alhonen, Ari Hirvonen, Jarmo Wahlfors, Riitta Sinervirta, Terho Eloranta et al.
      Pages 253-260

    4. Regulation of Polyamine Synthesis in Mammalian Cells

      • Lo Persson, Ingvar Holm, Louise Stjernborg, Olle Heby
      Pages 261-271

    5. Mechanisms Involved in Ornithine Decarboxylase Induction by 12-O-Tetradecanoylphorbol-13-Acetate, a Potent Mouse Skin Tumor Promoter and an Activator of Protein Kinase C

      • Ajit K. Verma, J. T. Hsieh, R. C. Pong
      Pages 273-290

    6. Polyamines, DNA Methylation and Cell Differentiation

      • Olle Heby, Lo Persson, Steven S. Smith
      Pages 291-299

    7. Two Phases of Ornithine Decarboxylase Activation During Lymphocyte Mitogenesis

      • Tomas Mustelin, Tiina Pessa, Seppo Lapinjoki, Jukka Gynther, Tomi Järvinen, Terho Eloranta et al.
      Pages 301-313

    8. Regulation of Protein Synthesis by Polyamines

      • Kazuei Igarashi, Kiyoshi Ito, Yuko Sakai, Toshihiro Ogasawara, Keiko Kashiwagi
      Pages 315-330

    9. Polyamine Recycling Enzymes in Human Cancer Cells

      • Heather M. Wallace, Mark E. Nuttall, Catherine S. Coleman
      Pages 331-344

    10. Estrogenic Control of Spermidine/Spermine N1-Acetyltransferase Activity in Rat Uterus

      • Antonio Perin, Angela Sessa, M. Alfonsina Desiderio
      Pages 345-351

    11. Erythrocyte Polyamines: Their Diagnostic and Therapeutic Importance in Human Neuro-Oncology

      • J.-Ph. Moulinoux, V. Quemener, J. Théron, R. Havouis, F. Darcel, Y. Guegan et al.
      Pages 353-363

    12. Abnormalities of Polyamine Biosynthesis in Spinal Cord of Totally Gastrectomized Rats

      • G. Scalabrino, M. E. Ferioli, E. Lorenzini, R. Candiani
      Pages 365-378

    13. Ornithine Decarboxylase and Polyamine Biosynthesis in Pancreatic Adaptation

      • Christian Löser, Ulrike Cleffmann, Frauke Alves, Ulrich R. Fölsch, Werner Creutzfeldt
      Pages 379-388

  3. Post-Synthetic Modifications of Proteins Involving Polyamines

    1. Front Matter

      Pages 389-389
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    2. Transglutaminases and Their Regulation: Implications for Polyamine Metabolism

      • Peter J. A. Davies, E. Antonio Chiocca, James P. Basilion, Susmita Poddar, Joseph P. Stein
      Pages 391-401
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Keywords

About this book

This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.

Editors and Affiliations

  • Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  • The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, USA

    Anthony E. Pegg

Bibliographic Information

  • Book Title: Progress in Polyamine Research

  • Book Subtitle: Novel Biochemical, Pharmacological, and Clinical Aspects

  • Editors: Vincenzo Zappia, Anthony E. Pegg

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5637-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1988

  • Softcover ISBN: 978-1-4684-5639-4Published: 12 December 2012

  • eBook ISBN: 978-1-4684-5637-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 780

  • Number of Illustrations: 69 b/w illustrations

  • Topics: Biochemistry, general

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

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