Cell Calcium Metabolism

1. Phosphoinositide Metabolism

   1. Activation of the Inositol-1,4,5-Trisphosphate Signaling System by Acute Ethanol Treatment of Rat Hepatocytes

      • Andrew P. Thomas, Jan B. Hoek, Raphael Rubin, Emanuel Rubin

      Pages 169-177

   2. Regulation of Hepatic Glycogenolysis by Calcium-Mobilizing Hormones

      • Peter F. Blackmore, Christopher J. Lynch, Stephen B. Bocckino, John H. Exton

      Pages 179-185

   3. Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca2+ Mobilization in the Human Platelet

      • Michael F. Crouch, Eduardo G. Lapetina

      Pages 187-192

   4. Specific Receptors for Inositol 1,4,5-Trisphosphate in Endocrine Target Tissues

      • Gaetan Guillemette, Tamas Balla, Albert J. Baukal, Kevin J. Catt

      Pages 193-203

   5. Intracellular Calcium Transients Associated with Endothelium-Derived Relaxing Factor Release May Be Mediated by Inositol-1,4,5-Trisphosphate

      • Alex L. Loeb, Nicholas J. Izzo Jr., Randolph M. Johnson, James C. Garrison, Michael J. Peach

      Pages 205-210

   6. Protein Kinase C in Rat Skeletal Muscle

      • Perry J. F. Cleland, Erik A. Richter, Stephen Rattigan, Eric Q. Colquhoun, Michael G. Clark

      Pages 211-219

   7. Activation of Phosphoinositide-Specific Phospholipase C by Ligands in the Presence of Guanine Nucleotides

      • John N. Fain, Michael A. Wallace, Richard J. H. Wojcikiewicz, Dejan Bojanic

      Pages 221-230

   8. Guanine Nucleotide-Dependent Release of Arachidonic Acid in Permeabilized Inflammatory Cells

      • Yukio Okano, Shigeru Nakashima, Toyohiko Tohmatsu, Kouji Yamada, Koh-Ichi Nagata, Yoshinori Nozawa

      Pages 231-236

2. Cell Proliferation and Differentiation

   1. Front Matter

      Pages 237-237

      PDF

   2. Measurement of Free Intracellular Calcium (Cai) in Fibroblasts

      • R. W. Tucker, K. Meade-Cobun, H. Loats

      Pages 239-248

   3. Growth Factors, Oncogenes, and Protein Kinase C

      • Ian G. Macara, George Gray, James Gaut, Anna Coco, Theresa Wingrove, Donna Faletto et al.

      Pages 249-254

   4. Insulin-like Growth Factor II Stimulates Calcium Influx in Competent Balb/c 3T3 Cells Primed with Epidermal Growth Factor

      • Ikuo Nishimoto, Etsuro Ogata, Itaru Kojima

      Pages 255-264

   5. Small Cell Lung Cancer Bombesin Receptors Utilize Calcium as a Second Messenger

      • Terry W. Moody, Anne N. Murphy, Samira Mahmoud, Gary Fiskum

      Pages 265-272

   6. Extracellular Ca2+ and Cell Cycle Transitions

      • Alton L. Boynton, Jean Zwiller, Timothy D. Hill, Thomas Nilsson, Per Arkhammer, Per-Olof Berggren

      Pages 273-282

   7. Role and Properties of Ligand-Induced Calcium Fluxes in Lymphocytes

      • Sergio Grinstein, Stephen Macdougall, Roy K. Cheung, Erwin W. Gelfand

      Pages 283-291

   8. Modulation of c-fos and c-myc Expression by Effectors of Ion Movements

      • Anthony F. Cutry, Alan J. Kinniburgh, Kirk J. Leister, C. E. Wenner

      Pages 293-303

   9. Regulation of c-fos Expression by Voltage-Dependent Calcium Channels

      • James I. Morgan, Tom Curran

      Pages 305-312

   10. Calcium Pulses, Waves, and Gradients in Early Development

       • Lionel F. Jaffe

       Pages 313-321

3. Regulation of Metabolism

   1. Front Matter

      Pages 323-323

      PDF

   2. Calcium Ions, Hormones, and Mammalian Oxidative Metabolism

      • James G. McCormack, Richard M. Denton

      Pages 325-330

A widespread appreciation for the role that calcium plays in cell physiology and patho­ physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth International Spring Symposium on Health Sciences at George Washington University in Washington, D. C. The participants in this unique meeting rep­ resented diverse fields of basic and clinical research, such as molecular physiology, oncology, molecular genetics, cardiology, bioenergetics, pathology, and endocrinology. The content of the proceedings of the symposium represents work in these and other areas of biomedical research. Organization of the book is aimed at striking a balance between the biochemistry 2 and physiology of normal cell Ca + metabolism and the pathological consequences of al­ 2 terations in cell Ca + homeostasis. The first section of the book is devoted to the transport mechanisms responsible for 2 2 regulating intracellular Ca + and the pharmacological modalities for controlling cell Ca + . Particular attention is given to the molecular basis for plasma membrane transport activities, 2 2 including the ATP-driven Ca + pump, the Na + -Ca + exchange system, and voltage sensitive 2 Ca + channels. The second section covers the exciting relationships between phosphoinositide metab­ 2 olism, signal transduction, and cell Ca + metabolism. This section begins with an eloquent overview by Professor Michael Berridge, who was the keynote speaker at the symposium and the recipient of the scientific merit award.

• ATP
• Calcium
• biochemistry
• chemistry
• clinical research
• endocrinology
• genetics
• membrane
• membrane transport
• metabolism
• molecular genetics
• physiology
• research
• signal transduction

• Departments of Biochemistry and Emergency Medicine, The George Washington University School of Medicine and Health Sciences, USA

  Gary Fiskum

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