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Targeting of Drugs

Anatomical and Physiological Considerations

  • Gregory Gregoriadis
  • George Poste

Part of the NATO ASI Series book series (NSSA, volume 155)

Table of contents

  1. Front Matter
    Pages iii-viii
  2. Albert Geerts, Luc Bouwens, Ronald De Zanger, Hans Van Bossuyt, Eddie Wisse
    Pages 1-14
  3. J. Clifford Steer, Peretz Weiss, Peter J. Wirth, Gilbert Ashwell
    Pages 29-43
  4. F. K. Jansen, C. Blazy, H. E. Blythman, B. Bourrie, P. Carayon, P. Casellas et al.
    Pages 81-91
  5. J. M. Derocq, G. Laurent, P. Casellas, H. Blythman, F. Jansen
    Pages 93-101
  6. Francis A. Drobniewski, Philip E. Thorpe, Philip M. Wallace, Edward J. Wawrzynczak
    Pages 103-108
  7. Gerrit L. Scherphof, Toss Daemen, Hans Derksen, George Lázár, Halbe H. Spanjer, Frits H. Roerdink
    Pages 109-120
  8. Carl Ritter, Charles Prood, Robert J. Rutman
    Pages 137-141
  9. A. J. Baillie
    Pages 143-151
  10. Gregory Gregoriadis, David Davis, Nathalie Garcon
    Pages 153-165
  11. Back Matter
    Pages 213-222

About this book

Introduction

A major vehicle for the transition of carrier-mediated drug delivery from a theoretical/experimental status to one with practical uses has been the NATO Advanced Studies Institute series "Targeting of Drugs". Three previous ASls of the series[1-3], also held in Cape Sounion, dealt with carriers of natural and synthetic origin, their preparation and drug incorporation as well as a wide range of applications. This book contains the proceedings of the 4th NATO ASI "Targeting of Drugs: Anatomical and Physiological Considerations" held in Cape Sounion, Greece during 20 June - 1 July 1987. Historically, carrier systems have been chosen on the basis of selective affinity for target sites. For instance, monoclonal antibodies bind selectively to antigens on the surface of cells and the same applies to ligands such as certain glycoproteins which bind to cell receptors. Colloidal carriers on the other hand, are "passively" targeted to the reticuloendothelial system. However, effective drug delivery depends not only on demonstration of affinity of the carrier system for its target but also, and perhaps crucially, on the way(s) by which the carrier-drug entity interacts with the interposed biological milieu. The book deals in depth with a number of biological milieus as travelled space for carriers en route to their destination, difficulties arising from unfavorable milieu-carrier interactions and ways to circumvent such difficulties. It also identifies, when possible, situations where proposed uses would or would not be realistic and provides perspectives for future goals.

Keywords

Antigen bone cancer cancer therapy cell drug drug delivery lipide research vaccine

Editors and affiliations

  • Gregory Gregoriadis
    • 1
  • George Poste
    • 2
  1. 1.Royal Free Hospital School of MedicineLondonUK
  2. 2.Smith Kline & French LaboratoriesPhiladelphiaUSA

Bibliographic information

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