Prostaglandin and Lipid Metabolism in Radiation Injury

  • Thomas L. WaldenJr.
  • Haywood N. Hughes

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Radiation Effects on Lipid Synthesis and Membrane Damage

    1. Front Matter
      Pages 1-1
    2. W. A. Cramp, A. M. George, J. C. Edwards, S. A. Sabovljev, G. Harris, L. E. Hart et al.
      Pages 59-72
    3. R. M. Price, D. M. Gersten, P. W. Ramwell
      Pages 79-83
    4. M. A. Stevenson, E. K. Farnum, G. M. Hahn, S. K. Calderwood
      Pages 85-90
    5. L. Szabo, W. R. Farkas
      Pages 109-114
    6. C. Kemal, L.-C. Yuan, K. Laurenzo
      Pages 121-126
    7. S. P. Chock, E. A. Schmauder-Chock
      Pages 127-132
  3. Radiation-Induced Changes in Eicosanoid Synthesis

    1. Front Matter
      Pages 133-133
    2. J. E. Hardcastle, S. Minoui
      Pages 173-178
    3. S. K. Calderwood, E. K. Farnum, M. A. Stevenson
      Pages 201-206
    4. Z. Weshler, A. Raz, E. Rosenmann, S. Biran, Z. Fuks, A. Eldor
      Pages 219-224
    5. A. Eldor, M. Cohn, I. Vlodavsky, E. Razin, E. Hy-Am, Z. Fuks et al.
      Pages 225-230
  4. Prostaglandins in Radiation Protection and Recovery

    1. Front Matter
      Pages 231-231
    2. M. R. Landauer, T. L. Walden, H. D. Davis, J. A. Dominitz
      Pages 245-251
    3. E. V. Holahan, W. F. Blakely, T. L. Walden
      Pages 253-262
  5. Clinical Implication

    1. Front Matter
      Pages 273-273
    2. P. W. Ramwell, M. L. Foegh, P. Kot
      Pages 275-281
    3. A. Dubois, E. D. Dorval, N. Fiala, L. K. Steel
      Pages 293-303
    4. I. F. Stamford, J. D. Gaffen, P. B. Melhuish, A. Bennett
      Pages 319-330
    5. W. R. Hanson, W. Jarnagin, K. DeLaurentiis, F. D. Malkinson
      Pages 331-338
    6. G. H. R. Rao, C. A. Cox, C. J. Witkop, J. G. White
      Pages 339-343
  6. Detection and Quantitation of Eicosanoids and Lipid Peroxides

    1. Front Matter
      Pages 353-353
    2. J. Maclouf, J. Grassi, P. Pradelles
      Pages 355-364
    3. W. C. Hubbard, C. L. Litterst, M. C. Liu, E. R. Bleecker, E. G. Mimnaugh, J. C. Eggleston et al.
      Pages 365-377
  7. Back Matter
    Pages 411-420

About this book


This volume contains the proceedings of the International Conference on Prostaglandins and Lipid Metabolism in Radiation Injury held in Rockville, Maryland, on October 2-3, 1986. Over 200 persons from eight countries attended the program, which consisted of 24 oral presentations and 38 poster presentations. Forty-two of those presentations have been included in this volume. The conference was sponsored by the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland. The effects of radiation on lipid synthesis and membrane damage are aptly summarized in the first five chapters. These chapters describe the effects of radiation on lipid peroxidation of model membranes, and the role of lipid composition in mammalian cell death and in bacterial radio- and thermosensitivity. In bacteria, lipid peroxidation is not essential for radiation-induced cell death. One of the key points of the conference was the paradoxical nature of the radiobiology of eicosanoids. On the one hand, eicosanoids are mediators of damage; on the other, they are radioprotective agents. It is clear from the literature and from the data presented at the conference that both of these properties may also be observed as a consequence of radiotherapy. Some studies indicate that nonsteroidal anti-inflammatory drugs may minimize or prevent certain radiation­ induced damage, but other studies show no positive effect.


Activation Ethylen Vivo bacteria cell cell culture cell membrane enzyme influence membrane metabolism oxidative metabolism prostaglandins quaternary structure tumors

Editors and affiliations

  • Thomas L. WaldenJr.
    • 1
  • Haywood N. Hughes
    • 1
  1. 1.Armed Forces Radiobiology Research InstituteBethesdaUSA

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