Models of Mental Disorders

A New Comparative Psychiatry

  • William T. McKinney

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. William T. McKinney
      Pages 1-4
  3. Fundamental Basis and Justification for a New Comparative Psychiatry

    1. Front Matter
      Pages 5-5
    2. William T. McKinney
      Pages 7-17
  4. Four Illustrative Case Examples

    1. Front Matter
      Pages 41-41
    2. William T. McKinney
      Pages 43-95
    3. William T. McKinney
      Pages 97-123
    4. William T. McKinney
      Pages 125-145
    5. William T. McKinney
      Pages 147-175
  5. Perspectives on the Animal Modeling Field

    1. Front Matter
      Pages 177-177
    2. William T. McKinney
      Pages 179-190
    3. William T. McKinney
      Pages 191-193
  6. Back Matter
    Pages 195-199

About this book


My ideas for this book have been evolving over the last several years as I have been working in the animal modeling area and have seen it change rather dramatically. There have been tremendous advances, both in methodology and in conceptualization, yet the literature is scattered in journals encompassing many disciplines. In particular, there have been only very limited attempts to write about the philosophical, conceptual, and controversial issues in this field; to pull together diverse findings; and to provide some general perspective on its future. As will probably be apparent, I am a clinical psychiatrist who also has a fundamental interest in animal behavior, especially primate social behavior. I entered the field from a clinical research standpoint to devel­ op some animal models of depression after being stimulated to do so by Dr. William Bunney, then at the National Institute of Mental Health and now at the University of California-Irvine. The field has grown rapidly since then and there is considerable research activity. Indeed, the re­ search activity has grown more rapidly than our conceptualization of what animal models are and are not. Animal preparations are now available for studying specific aspects of certain types of psychopathology. Thoughtful workers in the animal modeling field no longer talk about comprehensive models but rather about more limited experimental preparations in animals for studying certain specific aspects of human psychopathology.


Syndrom alcohol alcoholism anxiety disorder depression diagnosis hyperactivity methodology neurosis pharmacology psychiatry psychopathology schizophrenia stress syndromes

Authors and affiliations

  • William T. McKinney
    • 1
  1. 1.University of Wisconsin Medical SchoolMadisonUSA

Bibliographic information

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