DNA—Ligand Interactions

From Drugs to Proteins

  • Wilhelm Guschlbauer
  • Wolfram Saenger

Part of the NATO ASI Series book series (volume 137)

Table of contents

  1. Front Matter
    Pages i-x
  2. DNA Structure and Interaction with Small Molecules

  3. DNA — Protein Interactions: Repressor — Operator Systems

    1. Norbert Lehming, Juergen Sartorius, Brigitte von Wilcken-Bergmann, Benno Mueller-Hill
      Pages 173-182
    2. P. B. Sigler, A. Joachimiak, R. W. Schevitz, C. L. Lawson, R.-G. Zhang, Z. Otwinowski et al.
      Pages 183-184
    3. T. A. Steitz, L. Beese, B. Engelman, P. Freemont, J. Friedman, M. Sanderson et al.
      Pages 185-189
    4. R. Boelens, R. M. Scheek, R. M. J. N. Lamerichs, J. de Vlieg, J. H. van Boom, R. Kaptein
      Pages 191-215
  4. DNA — Protein Interactions: Methylation and Restriction Enzymes

    1. John M. Rosenberg, Judith A. McClarin, Christin A. Frederick, Bi-Cheng Wang, John Grable, Herbert W. Boyer et al.
      Pages 251-256
  5. Outlook: DNA-Protein Interactions of Complex Systems

    1. Marc Leng
      Pages 257-267
    2. Wolfram Saenger
      Pages 269-273
  6. Back Matter
    Pages 275-290

About this book


This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.


DNA biology molecular biology nucleic acid protein proteins

Editors and affiliations

  • Wilhelm Guschlbauer
    • 1
  • Wolfram Saenger
    • 2
  1. 1.Service de Biochimie, Bat. 142, Département de BiologieCentre d’Etudes Nucléaires de SaclayGif-sur-Yvette CedexFrance
  2. 2.Institut für KristallographieFreie UniversitätBerlin 33German Federal Republic

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