Mechanisms of Lymphocyte Activation and Immune Regulation

  • Sudhir Gupta
  • William E. Paul
  • Anthony S. Fauci

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)

Table of contents

  1. Front Matter
    Pages i-ix
  2. T Cell Receptor

    1. Philippa Marrack, Marcia McDuffie, Willi Born, Marica Blackman, Charles Hannum, John Kappler
      Pages 1-12
    2. M. M. Davis, N. R. J. Gascoigne, T. Lindsten, C. Goodnow, Y. Chien
      Pages 13-17
  3. T Cell Activation

    1. James C. Metcalfe, Gerry A. Smith, John P. Moore, Robin Hesketh
      Pages 29-44
    2. Arthur Weiss, John Imboden, Ken Hardy, John Stobo
      Pages 45-49
    3. P. C. L. Beverley, D. L. Wallace, K. O’Flynn, D. C. Linch
      Pages 51-58
    4. Claudio Milanese, Robert F. Siliciano, Neil E. Richardson, Hsiu-Ching Chang, Andres Alcover, Ellis L. Reinherz
      Pages 59-68
    5. Michael D. Cahalan, K. George Chandy, Thomas E. DeCoursey, Sudhir Gupta, Richard S. Lewis, Jeffrey B. Sutro
      Pages 85-101
  4. Interleukins and Their Receptors

    1. G. Scala, F. Ferrara, T. Pastore, F. Alfinito, R. Pizzano, L. Corbo et al.
      Pages 115-124
    2. Junji Yodoi, Masafumi Okada, Yutaka Tagaya, Yoshihisa Taniguchi, Keisuke Teshigawara, Tadashi Kasahara et al.
      Pages 139-148
    3. James N. Ihle, Yacob Weinstein, Ulf R. Rapp, John L. Cleveland, E. Premkumar Reddy
      Pages 149-162
  5. B Lymphocyte Activation, Proliferation and Differentiation

    1. Julian L. Ambrus Jr., Cynthia H. Jurgensen, Debra L. Bowen, Shohken Tomita, Toshimasa Nakagawa, Naoko Nakagawa et al.
      Pages 163-175
    2. J. C. Cambier, J. T. Ransom, L. K. Harris, K. M. Coggeshall, Z. Z. Chen, M. K. Newell et al.
      Pages 195-205
    3. William E. Paul, Junichiro Mizuguchi, Michael A. Beaven, Peter Hornbeck, Wayne Tsang, Junichi Ohara
      Pages 207-214
    4. Susan L. Swain, Richard W. Dutton
      Pages 215-225
    5. Paschalis Sideras, Susanne Bergstedt-Lindqvist, Eva Severinson, Yoshihiko Noma, Takayuki Naito, Chihiro Azuma et al.
      Pages 227-236
    6. Bharathi Vayuvegula, Sastry Gollapudi, Sudhir Gupta
      Pages 237-240
  6. Proto-Oncogenes and Cellular Activation and Differentiation

    1. John C. Reed, Michael B. Prystowsky, Jeffrey A. Kern, James D. Alpers, Peter C. Nowell, Richard G. Hoover
      Pages 249-262
    2. Charles Van Beveren, Richard L. Mitchell, Cynthia Henning-Chubb, Eliezer Huberman, Inder M. Verma
      Pages 263-274
  7. Natural Killing and Cyclosporin A

    1. Giorgio Trinchieri, Lucille London, Michiko Kobayashi, Bice Perussia
      Pages 285-298
    2. Allan D. Hess, Paul M. Colombani
      Pages 309-330
  8. Back Matter
    Pages 331-337

About this book


During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.


Activation Interleukin 1 cell gene gene expression leukemia membrane regulation

Editors and affiliations

  • Sudhir Gupta
    • 1
  • William E. Paul
    • 2
  • Anthony S. Fauci
    • 2
  1. 1.University of CaliforniaIrvineUSA
  2. 2.National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5325-6
  • Online ISBN 978-1-4684-5323-2
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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