Biophysics of the Pancreatic β-Cell

  • Illani Atwater
  • Eduardo Rojas
  • Bernat Soria

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Table of contents

  1. Front Matter
    Pages i-xii
  2. New Experimental Approaches

  3. K-Channels

    1. F. M. Ashcroft, D. E. Harrison, S. J. H. Ashcroft
      Pages 53-62
    2. D. L. Cook, C. N. Hales, L. S. Satin
      Pages 63-67
    3. M. L. J. Ashford, N. C. Sturgess, D. L. Cook, C. N. Hales
      Pages 69-76
    4. O. H. Petersen, I. Findlay, M. J. Dunne
      Pages 77-82
    5. J. C. Henquin, M. G. Garrino, M. Nenquin, G. Paolisso, M. Hermans
      Pages 83-93
    6. R. M. Santos, H. Finol, E. Rojas
      Pages 109-123
    7. J. Lopez-Barneo, L. Tabares, A. Castellano
      Pages 125-137
  4. Ca-Channels

  5. Role of Ionic Channels

    1. P. C. Croghan, C. M. Dawson, A. M. Scott, J. A. Bangham
      Pages 207-223
    2. C. M. Dawson, P. C. Croghan
      Pages 225-225
    3. B. Soria, Rosa Ferrer
      Pages 235-246
    4. J. A. Bangham, P. A. Smith, P. C. Croghan
      Pages 265-278
  6. Intracellular Ionized Calcium

  7. Neural Regulation

    1. L. A. Campfield, F. J. Smith, J. E. Settle, R. Sohaey
      Pages 343-349
    2. I. Palafox, J. V. Sanchez-Andres, S. Sala, R. Ferrer, B. Soria
      Pages 351-358
    3. J. M. Pou, T. Cervera, M. Codina, A. de Leiva
      Pages 367-368
  8. Mechanisms of Insulin Release

    1. H. B. Pollard, K. W. Brocklehurst, E. J. Forsberg, A. Stutzin, G. Lee, A. L. Burns
      Pages 369-383
    2. J. C. Hutton, M. Peshavaria, H. W. Davidson, K. Grimaldi, R. Pogge Von Strandmann, K. Siddle
      Pages 385-396
    3. A. Kanatsuka, H. Makino, N. Hashimoto, M. Sakurada, S. Yoshida
      Pages 397-401
    4. I. Valverde, P. Garcia-Morales, M. Saceda, W. J. Malaisse
      Pages 403-407
    5. J. J. Osuna, R. Rubio, E. Rodriguez, C. Osorio
      Pages 429-430
    6. J. E. Campillo, P. Mena, S. Alejo, C. Barriga
      Pages 431-442
    7. R. Gomis, C. Alarcon, I. Valverde, W. J. Malaisse
      Pages 443-446
    8. F. M. Matschinsky, M. Meglasson, A. Ghosh, M. Appel, F. Bedoya, M. Prentki et al.
      Pages 459-469
  9. Back Matter
    Pages 471-494

About this book


Pancreatic a-cell biophysics has undergone a veritable informa­ tion explosion in the past two years. Single channel and macroscopic currents have become easily accessible following the introduction of the patch clamp technique. In addition to this new approach, further development of techniques for optical measurements, ion-sensitive microelectrodes, permeabilized cells and mathematical modelling have recently added to the now classical techniques of membrane potential recording and tracer flux measurement. The International Workshop on Biophysics of the Pancreatic a-Cell held in Alicante (Spain) on Sep­ tember 30 - October 1, 1985, has now given us the opportunity to share experiences with these new techniques applied to the a-cell. Further­ more this was the first occasion for most of the groups doing patch­ clamp studies of the a-cell to decide on appropriate nomenclature and to debate the different characteristics of the a-cell ionic channels. To make this information available to the larger scientific community a record of the meeting has been assembled in this book. It is a collection of research papers by leading scientists at the meet­ ing working on biophysical, biochemical and physiological aspects. of secretion. We grouped their contributions in seven sections, includ­ ing new experimental approaches, K-channels, Ca-channels, role of ionic channels, intracellular ionized calcium, neural regulation and mechanisms of insulin release. Each section gives an account of the state of the problem at the time of the meeting, and the subjects are analyzed from the different perspectives of the various contributors.


Calcium biophysics cells membrane regulation

Editors and affiliations

  • Illani Atwater
    • 1
  • Eduardo Rojas
    • 1
  • Bernat Soria
    • 2
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.University of AlicanteAlicanteSpain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5316-4
  • Online ISBN 978-1-4684-5314-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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