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Targeting of Drugs With Synthetic Systems

  • Gregory Gregoriadis
  • Judith Senior
  • George Poste

Part of the NATO ASI Series book series (NSSA, volume 113)

Table of contents

  1. Front Matter
    Pages i-viii
  2. John A. Summerfield
    Pages 1-12
  3. P. S. Ringrose, M. J. Humphrey
    Pages 65-86
  4. S. S. Davis, S. J. Douglas, L. Illum, P. D. E. Jones, E. Mak, R. H. Muller
    Pages 123-146
  5. P. Couvreur, V. Lenaerts, A. Ibrahim, L. Grislain, L. Van Snick, P. Guiot et al.
    Pages 147-164
  6. Paolo Ferruti
    Pages 165-182
  7. Gregory Gregoriadis, Judith Senior
    Pages 183-192
  8. Frits Roerdink, Joke Regts, Toos Daemen, Irma Bakker-Woudenberg, Gerrit Scherphof
    Pages 193-206
  9. Deborah A. Eppstein
    Pages 207-219
  10. Gabriel Lopez-Berestein, Rudolph L. Juliano, Kapil Mehta, Reeta Mehta, Teresa McQueen, Roy L. Hopfer
    Pages 221-228
  11. Alberto Gabizon, Dorit Goren, Avner Ramu, Yechezkel Barenholz
    Pages 229-238
  12. R. H. Muller, S. S. Davis, L. Illum, E. Mak
    Pages 239-263
  13. D. J. A. Crommelin, G. J. Fransen, P. J. M. Salemink
    Pages 277-287
  14. Back Matter
    Pages 289-299

About this book

Introduction

Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ­ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharmacological action were discussed in the two previous NATO Advanced Studies Institutes (ASI) of this series, "Targeting of Drugs" and "Receptor-Mediated Targeting of Drugs", the proceedings of wh ich were published by Plenum in 1982 and 1984 respectively. This book contains the proceedings of the 3rd NATO ASI "Targeting of Drugs with Synthetic Systems" held as be fore at Cape Sounion, Greece during 24 June-5 July 1985. It deals mostly with man-made carriers such as a variety of polymers, matrices, liposomes and other colloidal micro­ particles. The twenty chapters discuss the interaction of such carriers with the biological milieu, approaches to bypass the reticuloendothelial system (or, when needed, take advantage of its interception of carriers to optimally deliver drugs to phagocytes) and ways to improve delivery to specific cells, often with the help of carrier-linked ligands.

Keywords

biological cells colloid enzyme enzymes glycoprotein liposomes particles pharmacology polymer protein proteins receptors system toxicity

Editors and affiliations

  • Gregory Gregoriadis
    • 1
  • Judith Senior
    • 1
  • George Poste
    • 2
  1. 1.Royal Free Hospital School of MedicineLondonEngland
  2. 2.Smith Kline & French LaboratoriesPhiladelphiaUSA

Bibliographic information

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