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Structure and Dynamics of RNA

  • P. H. van Knippenberg
  • C. W. Hilbers

Part of the NATO ASI Series book series (NSSA, volume 110)

Table of contents

  1. Front Matter
    Pages i-ix
  2. D. H. Turner, S. M. Freier, N. Sugimoto, D. R. Hickey, J. A. Jaeger, A. Sinclair et al.
    Pages 1-13
  3. Jean Louis Leroy, Daniel Broseta, Nicolas Bolo, Maurice Guéron
    Pages 31-44
  4. Ignacio Tinoco Jr., Phillip Cruz, Peter Davis, Kathleen Hall, Charles C. Hardin, Richard A. Mathies et al.
    Pages 55-68
  5. P. Lowary, J. Sampson, J. Milligan, D. Groebe, O. C. Uhlenbeck
    Pages 69-76
  6. Cornelis W. A. Pleij, Alex van Belkum, Krijn Rietveld, L. Bosch
    Pages 87-98
  7. A. G. Redfield, B.-S. Choi, R. H. Griffey, M. Jarema, P. Rosevear, P. Hoben et al.
    Pages 99-112
  8. D. Moras, P. Dumas, E. Westhof
    Pages 113-124
  9. Richard Giegé, Anne-Catherine Dock, Philippe Dumas, Jean-Pierre Ebel, Pascale Romby, Eric Westhof et al.
    Pages 125-136
  10. Rupert De Wachter
    Pages 191-204
  11. Martin Digweed, Tomas Pieler, Volker A. Erdmann
    Pages 205-219
  12. Asser Andersen, Niels Larsen, Henrik Leffers, Jørgen Kjems, Roger Garrett
    Pages 221-237
  13. P. Sloof, R. Benne, B. F. De Vries
    Pages 253-264
  14. A. Dahlberg, W. Jacob, M. Santer, C. Zwieb, D. Jemiolo
    Pages 265-271
  15. James Ofengand, Jerzy Ciesiolka, Kelvin Nurse
    Pages 273-287
  16. V. Eckert, A. Lang, A. Kyriatsoulis, H. G. Gassen
    Pages 289-301
  17. Thomas R. Cech, Francis X. Sullivan, Tan Inoue, John M. Burke, Michael D. Been, N. Kyle Tanner et al.
    Pages 303-308
  18. Henk F. Tabak, Annika C. Arnberg, Gerda van der Horst
    Pages 309-314
  19. Gerhard Steger, Volker Rosenbaum, Detlev Riesner
    Pages 315-329
  20. Back Matter
    Pages 331-337

About this book

Introduction

This volume contains contributions from the speakers at the NATO Advanced Research Workshop on "3D 5tructure and Dynamics of RNA", which was held in Renesse, The Netherlands, 21 - 24 August, 1985. Two major developments have determined the progress of nucleic acid research during the last decade. First, manipulation of genetic material by recombinant DNA methodology has enabled detailed studies of the function of nucleic acids in vivo. 5econd, the use of powerful physical methods, such as X-ray diffraction and nuclear magnetic resonance spectroscopy, in the study of biomacromolecules has provided information regarding the structure and the dynamics of nucleic acids. Both developments were enabled by the advance of synthetic methods that allow preparation of nucleic acid molecules of required sequence and length. The basic understanding of nucleic acid function will ultimately depend on a close collaboration between molecular biologists and biophy­ sicists. In the case of RNA, the ground rules for the formation of secondary structure have been derived from physical studies of oligoribonucleotides. Powerfull spectroscopic techniques have revealed more details of ~~A structure including novel conformations (e.g. left-handed Z-RNA). A wealth of information has been obtained by studying the relatively small transfer RNA molecules. A few of these RNAs have been crystallized, enabling determination of their three-dimensional structure. It has become apparent that "non-classical" basepairing between distal nucleotides gives rise to tertiary interactions, determining the overall shape of the molecule.

Keywords

DNA X-ray acid development diffraction dynamics information kinetics magnetic resonance magnetic resonance spectroscopy nuclear magnetic resonance research resonance structural dynamics structure

Editors and affiliations

  • P. H. van Knippenberg
    • 1
  • C. W. Hilbers
    • 2
  1. 1.University of LeidenLeidenThe Netherlands
  2. 2.University of NijmegenNijmegenThe Netherlands

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