Biological Reactive Intermediates III

Mechanisms of Action in Animal Models and Human Disease

  • James J. Kocsis
  • David J. Jollow
  • Charlotte M. Witmer
  • Judd O. Nelson
  • Robert Snyder

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Years with Elizabeth and James Miller: in Appreciation

  3. Chemistry and Biology of Biological Reactive Intermediates

  4. Biology of Cytochrome P-450 and Related Aspects of the Mixed Function Oxidase

    1. F. Peter Guengerich, Tsutomu Shimada, Diane R. Umbenhauer, Martha V. Martin, Kunio S. Misono, Linda M. Distlerath et al.
      Pages 83-94
    2. Paul E. Thomas, Linda M. Reik, Sarah L. Maines, Stelvio Bandiera, Dene E. Ryan, Wayne Levin
      Pages 95-106
    3. John B. Schenkman, Leonard V. Favreau, Ingela Jansson
      Pages 107-117
    4. Jeffrey Baron, Jeffrey M. Voigt, Tyrone B. Whitter, Thomas T. Kawabata, Shirley A. Knapp, F. Peter Guengerich et al.
      Pages 119-144
    5. Fred K. Friedman, Sang S. Park, Byung J. Song, Kuo C. Cheng, Harry V. Gelboin, T. Fujino
      Pages 145-154
  5. Suicide Substrates of Cytochrome P-450

    1. Patrick M. Dansette, Marcel Delaforge, Eric Sartori, Philippe Beaune, Maryse Jaouen, Daniel Mansuy
      Pages 155-162
  6. Characterization and Toxicological Significance of Phase II Enzymes

    1. Karl Walter Bock, Barbara S. Bock-Hennig, Gösta Fischer, Werner Lilienblum, Gerhard Schirmer
      Pages 171-184
    2. Cecil B. Pickett, Claudia A. Telakowski-Hopkins, Gloria J.-F. Ding, Victor D.-H. Ding
      Pages 185-193
    3. Franz Oesch, Ludwig Schladt, Renate Hartmann, Christopher Timms, Walter Wörner
      Pages 195-201
  7. Short Communications

    1. Minro Watanabe, Tetsuo Ohmachi, Ikuko Sagami
      Pages 203-212
    2. Susan K. Gilmour, George F. Kalf, Robert Snyder
      Pages 223-235
    3. T. R. Tephly, K. A. Black, M. D. Green, B. L. Coffman, G. A. Dannan, F. P. Guengerich
      Pages 243-251
    4. Helen W. Davies, Paul E. Thomas, Lance R. Pohl
      Pages 253-261
    5. T. P. Coogan, D. G. Stump, D. A. Barsotti, I. Y. Rosenblum
      Pages 281-290
    6. David C. Thompson, Young Nam Cha, Michael A. Trush
      Pages 301-309
    7. David Ross, Peter Moldeus
      Pages 329-335
    8. Michael D. Wand, John A. Thompson
      Pages 337-346
    9. Howard G. Shertzer, Michael P. Niemi, M. Wilson Tabor
      Pages 347-356
    10. S. J. Stohs, Z. F. Al-Bayati, M. Q. Hassan, W. J. Murray, H. A. Mohammadpour
      Pages 357-365
    11. Garold S. Yost, Mark R. Nocerini, James R. Carlson, Daniel J. Liberato
      Pages 373-380
    12. Michael W. Duffel, Maria N. Janss
      Pages 415-422
    13. Richard B. van Breemen, Catherine C. Fenselau, Deanne M. Dulik
      Pages 423-429
    14. H. W. Ruelius, S. K. Kirkman, E. M. Young, F. W. Janssen
      Pages 431-441
  8. Role of Sulfur in Metabolic Activation and Detoxication

  9. Active Oxygen and Thiol Oxidations

    1. Steven D. Aust, Craig E. Thomas, Lee A. Morehouse, Morio Saito, John R. Bucher
      Pages 513-526

About this book


This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.


growth metabolism nucleic acid protein proteins toxicology

Editors and affiliations

  • James J. Kocsis
    • 1
  • David J. Jollow
    • 2
  • Charlotte M. Witmer
    • 3
  • Judd O. Nelson
    • 4
  • Robert Snyder
    • 3
  1. 1.Thomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Medical University of South CarolinaCharlestonUSA
  3. 3.Rutgers UniversityPiscatawayUSA
  4. 4.University of MarylandCollege ParkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5136-8
  • Online ISBN 978-1-4684-5134-4
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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