Immune Deficiency and Cancer

Epstein-Barr Virus and Lymphoproliferative Malignancies

  • David T. Purtilo

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Immune Deficiency, Epstein-Barr Virus (EBV) and Lymphoproliferative Disorders

  3. Classical Epstein-Barr Virus Associated Disorders

    1. James Linder, David T. Purtilo
      Pages 11-36
    2. Gerhard R. F. Krueger
      Pages 37-68
    3. James Linder, David T. Purtilo
      Pages 69-99
  4. Inherited Immune Deficiency and Lymphoproliferative Malignancies

    1. Shinji Harada, Eiji Tatsumi, Helen Lipscomb, David T. Purtilo
      Pages 123-141
  5. Model Systems for Epstein-Barr Virus-Target Cell Interaction

  6. Acquired Immune Deficiency and Lymphoproliferative Disorders

    1. Israel Penn
      Pages 281-308
    2. Charles P. Bieber, Richard L. Heberling, S. W. Jamieson, Phillip E. Oyer, Michael Cleary, Roger Warnke et al.
      Pages 309-320
    3. Douglas W. Hanto, Glauco Frizzera, Kazimiera J. Gajl-Peczalska, David T. Purtilo, Richard L. Simmons
      Pages 321-347
    4. Martin Tobi, Abraham Morag
      Pages 349-366
    5. Joseph A. Sonnabend, Steven S. Witkin, Ruth B. Purtilo, David T. Purtilo
      Pages 367-384
  7. Genetic Factors in Lymphomagenesis

    1. Henry T. Lynch, Guy S. Schuelke
      Pages 401-425
  8. Prevention of Epstein-Barr Induced Diseases in Immunodeficient Individuals

    1. Milan Fiala, Satya N. Chatterjee
      Pages 443-456
    2. Hilaire J. Meuwissen, David T. Purtilo
      Pages 457-469
  9. Back Matter
    Pages 481-488

About this book


The discoveries of Burkitt, Epstein, and Henle have laid the foundation for continuing generation of information regarding the mechanisms of induction of diseases by Epstein-Barr virus. The discovery of the virus two decades ago resulted from clinical and basic science collaborative studies on Burkitt lymphoma. Subse­ quently, nasopharyngeal carcinoma and infectious mononucleosis have been linked etiologically with the virus. During the first decade of research following the discovery of the virus, the mechanisms for the induction of BL, NPC, and IM were sought. At that time one prevailing view was that individual oncogenic strains of EBV were responsible for the different disorders. Paralleling the development of immunology in the 1970's was the accrual of knowledge about immunological events occurring during IM. These studies suggest that immune defense mechanisms deter­ mine the outcome of this viral infection rather than different viral strains. During the early 1970's, Starzl and Penn and Gatti and Good had noted an increased frequency of malignancy in renal allograft recipients and children with primary immune deficiency disorders, respectively. These observations provoked investigators to restudy the role of immune surveillance against malignancy. At that time immune surveillance was thought to occur against tumor-specific antigens; thereby neoplasms were eliminated.


antigen cancer cancer registry carcinoma cell children diseases immunology infectious interferon lymphoma pathology prevention research transplantation

Editors and affiliations

  • David T. Purtilo
    • 1
  1. 1.University of Nebraska Medical CenterOmahaUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Publishing Corporation 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4762-0
  • Online ISBN 978-1-4684-4760-6
  • Buy this book on publisher's site
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