Contractile Mechanisms in Muscle

  • Gerald H. Pollack
  • Haruo Sugi

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Structural Dynamics

    1. Front Matter
      Pages 1-1
    2. Structure of the Myofilaments

      1. Rhea J. C. Levine
        Pages 3-4
      2. Arthur J. Rowe, Maria C. Maw
        Pages 5-20
      3. Takeyuki Wakabayashi, Chikashi Toyoshima, Eisaku Katayama
        Pages 21-28
      4. Thomas F. Robinson, Leona Cohen-Gould
        Pages 47-61
    3. Do Thick Filaments Shorten?

      1. Gerald H. Pollack, Haruo Sugi
        Pages 65-66
      2. M. M. Dewey, P. Brink, D. E. Colflesh, B. Gaylinn, S.-F. Fan, F. Anapol
        Pages 67-87
      3. Rhea J. C. Levine, Robert W. Kensler, Mary Reedy, Waltraud Hoffman, Sandra Davidheiser, Robert E. Davies
        Pages 93-106
    4. X-ray Diffraction Approaches to Structural Dynamics

    5. Structural Basis of Forces in Resting Muscle

      1. Alan Magid
        Pages 267-268
      2. Mark Schoenberg, B. Brenner, J. M. Chalovich, L. E. Greene, E. Eisenberg
        Pages 269-284
      3. Alan Magid, H. P. Ting-Beall, Melanie Carvell, Theda Kontis, Carmen Lucaveche
        Pages 307-328
    6. The Composition of the Intracellular Milieu

      1. David Maughan
        Pages 331-332
      2. D. R. Wilkie, M. J. Dawson, R. H. T. Edwards, R. E. Gordon, D. Shaw
        Pages 333-347
      3. Nancy A. Curtin
        Pages 349-351
    7. Do Cross-Bridges Rotate During Contraction?

      1. Roger Cooke
        Pages 371-372
      2. K. C. Holmes, R. S. Goody
        Pages 373-384
      3. Roger Cooke, Mark S. Crowder, Christine H. Wendt, Vincent A. Barnett, David D. Thomas
        Pages 413-427
      4. H. Shimizu
        Pages 429-436
    8. Concluding Discussion

      1. Gerald H. Pollack, Haruo Sugi
        Pages 439-450
  3. Mechanics, Energetics and Molecular Models

    1. Front Matter
      Pages 451-451
    2. Molecular Models

About this book


Prior to the emergence of the sliding filament model, contraction theories had been in abundance. In the absence of the kinds of structural and biochemical information available today, it has been a simple matter to speculate about the possible ways in which tension generation and shortening might occur. The advent of the sliding filament model had an immediate impact on these theories; within several years they fell by the wayside, and attention was redirected towards mechanisms by which the filaments might be driven to slide by one another. In terms of identifying the driving mechanism, the pivotal observa­ tion was the electron micrographic indentification of cross-bridges extending from the thick filaments. It was quite naturally assumed that such bridges, which had the ability to split ATP, were the molecular motors, i.e., that they were the sites of mechanochemical transduction. Out of this presumption grew the cross-bridge model. in which filament sliding is presumed to be driven by the cyclic interaction of cross-bridges with complementary actin sites located along the thin filaments.


attention cell muscle

Editors and affiliations

  • Gerald H. Pollack
    • 1
  • Haruo Sugi
    • 2
  1. 1.University of Washington School of MedicineSeattleUSA
  2. 2.Teikyo University School of MedicineTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4705-7
  • Online ISBN 978-1-4684-4703-3
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals