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Immunobiology of Parasites and Parasitic Infections

  • John J. Marchalonis

Part of the Contemporary Topics in Immunobiology book series (CTI, volume 12)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Joseph F. Albright, Julia W. Albright
    Pages 1-52
  3. Nadia Nogueira
    Pages 53-69
  4. Luc H. Perrin, L. Rodriguez da Silva, R. Dayal
    Pages 109-125
  5. Georges E. Roelants, Margaret Pinder
    Pages 225-274
  6. Mario Philipp, M. J. Worms, R. M. Maizels, Bridget M. Ogilvie
    Pages 275-321
  7. Graham F. Mitchell, Robin F. Anders, Colin B. Chapman, Ian C. Roberts-Thomson, Emanuela Handman, Kathy M. Cruise et al.
    Pages 323-358
  8. Raymond T. Damian
    Pages 359-420
  9. S. Michael Phillips, Edward G. Fox
    Pages 421-461
  10. Back Matter
    Pages 491-497

About this book

Introduction

The phenomena involved in infections of man and domestic animals with metazoan or protozoan parasites present formidable practical problems as well as a theoretical challenge to immunologists, molecular biologists, and evolu­ tionary biologists. With respect to the public health and economic problems, malaria, for example, remains a major health problem with approximately 200 million people being infected yearly and, on the basis of World Health Organiza­ tion estimates, more than 1 million children die each year of malaria infections (Chapter 4). This volume addresses state-of-the-art immunologic approaches to the development of vaccines for parasitic diseases (Chapter 9) and analyses of studies bearing on the antigenic characterization of protozoan and metazoan parasites (Chapters 4, 5, and 7), on investigations of the role of precise mecha­ nisms underlying natural resistance or non permissiveness of the host to parasitic infections (Chapters 1, 2, and 12), on induced mechanisms including the genera­ tion of parasite-specific T-cell lines and clones (Chapter 6), and on the generation of monoclonal antibodies (Chapters 4 and 5) to parasite antigens of distinct de­ velopmental stages. Great progress has been made in characterizing parasite antigens capable of inducing a protective response in the vaccinated host; further progress in this area strongly depends on biochemistry and molecular biology with the long-term goal of synthesizing such antigens chemically or producing them by means of recombinant DNA technology (Chapter 4).

Keywords

DNA antibody antigen biochemistry biology diseases immunobiology infection infections malaria molecular biology parasite protozoa resistance vaccine

Editors and affiliations

  • John J. Marchalonis
    • 1
  1. 1.Medical University of South CarolinaCharlestonUSA

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