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Handbook of Neurochemistry

Volume 6: Receptors in the Nervous System

  • Abel Lajtha
Book

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Michael Williams
    Pages 1-26
  3. Anna Borsodi, Maria Wollemann
    Pages 27-38
  4. Maria Wollemann, Anna Borsodi
    Pages 39-50
  5. Marianne Fillenz
    Pages 51-69
  6. Bertha Kalifon Madras
    Pages 71-106
  7. M. Hamon, S. Bourgoin, S. El Mestikawy, C. Goetz
    Pages 107-143
  8. Lindsay B. Hough, Jack Peter Green
    Pages 145-211
  9. G. A. R. Johnston, R. D. Allan, J. H. Skerritt
    Pages 213-237
  10. Najam A. Sharif
    Pages 239-259
  11. Richard F. Squires
    Pages 261-306
  12. De-Maw Chuang, E. Costa
    Pages 307-330
  13. Eric J. Simon
    Pages 331-352
  14. David R. Burt, Najam A. Sharif
    Pages 353-378
  15. Patrick L. McGeer, Edith G. McGeer
    Pages 379-410
  16. Edith D. Hendley
    Pages 411-429
  17. Maurizio Raiteri, Mario Marchi, Guido Maura
    Pages 431-462
  18. Neville N. Osborne
    Pages 511-526
  19. Fusao Hirata
    Pages 527-539
  20. Yigal H. Ehrlich
    Pages 541-574
  21. Kelvin W. Gee, Frederick J. Ehlert, William R. Roeske, Henry I. Yamamura
    Pages 575-593
  22. Benjamin Weiss, M. Blair Clark, Louise H. Greenberg
    Pages 595-627
  23. S. J. Enna
    Pages 629-638
  24. Jack W. Schweitzer, Kenneth A. Bonnet, Arnold J. Friedhoff
    Pages 639-660
  25. Back Matter
    Pages 661-668

About this book

Introduction

A major advance in the biological sciences in the past decade has been the biochemical identification of cell membrane receptors. The existence of re­ ceptor substances on the surface of cells that recognize and bind to extracellular molecules was proposed at the beginning of the century by the pharmacologist and immunologist Paul Ehrlich and the physiologist J. N. Langley. Since then, receptors have been found to play an important role in numerous physiological and pathological processes. Over the years many attempts have been made to physically isolate and chemically characterize receptors, but because of the receptors' extremely low concentration and membrane localization, these ef­ forts have met with limited success. Yet, despite the failure to characterize receptor substances, the concept of the presence of such molecules has had considerable heuristic value. Using pharmacological, physiological, and im­ munologic approaches, researchers have identified several specific receptors, e. g. , a-and ~-adrenergic, nicotinic and muscarinic cholinergic, and histami­ nergic. With the characterization of various types of receptors on cell mem­ branes, many drugs were developed that proved to be experimentally and ther­ apeutically useful. It was only in the early 1970s that methods for the specific measurement, chemical characterization, and physical isolation of cell membrane receptors were developed. These advances were made possible by the availability of ligands with high specific radioactivity that retained their biological activity and of experimental procedures that differentiated between specific and non­ specific binding of ligands.

Keywords

adenosine brain catecholamines cognition experiment nervous system neurons research

Editors and affiliations

  • Abel Lajtha
    • 1
  1. 1.Center for NeurochemistryWards IslandUSA

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