© 1984

Purine Metabolism in Man-IV

Part A: Clinical and Therapeutic Aspects; Regulatory Mechanisms

  • Chris H. M. M. De Bruyn
  • H. Anne Simmonds
  • Mathias M. Müller

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Recent Advances in Diagnosis and Treatment of Purine and Pyrimidine Disorders

    1. Phosphoribosyltransferase Deficiencies

      1. M. J. Dillon, H. A. Simmonds, T. M. Barratt, L. D. Fairbanks, P. C. Holland
        Pages 1-6
      2. N. Ogasawara, S. Kashiwamata, H. Oishi, K. Hara, K. Watanabe, S. Miyazaki et al.
        Pages 13-18
      3. H. E. Gruber, M. Vuchinich, T. A. Marlow, M. M. Plent, R. C. Willis, J. E. Seegmiller et al.
        Pages 19-22
      4. N. Lawrence Edwards, Walter Jeryc, Irving H. Fox
        Pages 23-26
      5. P. Banholzer, W. Gröbner, W. Löffler, S. Reiter, N. Zöllner
        Pages 27-31
    2. Adenosine Deaminase Deficiency

      1. R. J. Levinsky, E. G. Davies, H. A. Simmonds, D. R. Webster, M. Adinolfi
        Pages 33-38
      2. Morton J. Cowan, David W. Martin Jr., Diane W. Wara, Arthur J. Ammann
        Pages 39-45
      3. Charles Beauchamp, Peter E. Daddona, David P. Menapace
        Pages 47-52
    3. Purine Nucleoside Phosphorylase Deficiency

      1. A. R. Watson, H. A. Simmonds, D. R. Webster, L. Layward, D. I. K. Evans
        Pages 53-59
      2. J. W. Stoop, B. J. M. Zegers, L. J. M. Spaapen, W. Kuis, J. J. Roord, G. T. Rijkers et al.
        Pages 61-66
    4. Ecto-5′-Nucleotidase Deficiency

      1. A. D. B. Webster, T. Shah, T. J. Peters
        Pages 67-72
    5. Xanthine Oxidase Deficiency

      1. K. Nishioka, H. Yamanaka, T. Nishina, T. Hosoya, K. Mikanagi
        Pages 73-76
    6. Myoadenylate Deaminase Deficiency

      1. William N. Fishbein
        Pages 77-84
      2. E. Joosten, C. van Bennekom, F. Oerlemans, C. De Bruyn, T. Oei, J. Trijbels
        Pages 85-89
    7. Phosphoribosylpyrophosphate Synthetase Mutants

    8. Defects of Pyrimidine Metabolism

      1. S. K. Wadman, F. A. Beemer, P. K. de Bree, M. Duran, A. H. van Gennip, D. Ketting et al.
        Pages 109-114

About this book


These two volumes, entitled "Purine Metabolism in Man IV" con­ tain the paper presented at the "IV. International Symposium on Human Purine and Pyrimidine Metabolism," held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet­ ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo­ lism under normal and pathological conditions has been growing rapid­ ly. Apart from the more or less classical topics such as hyperuricae­ mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse­ quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been re­ ported which indicate clear differences in the pathways of ATP metabo­ lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel­ oped.


ATP Purine Pyrimidine cancer metabolism parasites

Editors and affiliations

  • Chris H. M. M. De Bruyn
    • 1
  • H. Anne Simmonds
    • 2
  • Mathias M. Müller
    • 3
  1. 1.University of Nijmegen Faculty of MedicineNijmegenThe Netherlands
  2. 2.Guy’s Hospital Medical SchoolLondonUK
  3. 3.University of ViennaViennaAustria

Bibliographic information

  • Book Title Purine Metabolism in Man-IV
  • Book Subtitle Part A: Clinical and Therapeutic Aspects; Regulatory Mechanisms
  • Editors Chris H. De Bruyn
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer-Verlag US 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-41363-6
  • Softcover ISBN 978-1-4684-4555-8
  • eBook ISBN 978-1-4684-4553-4
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XVII, 555
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biochemistry, general
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing
Health & Hospitals
Consumer Packaged Goods