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Drug Metabolite Isolation and Determination

  • Eric Reid
  • J. P. Leppard

Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 12)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Techniques Applicable to Metabolite Investigation

  3. NOTES and COMMENTS relating to Techniques applicable to metabolite investigation

  4. Investigation of Metabolites, Especially Phase I

    1. Front Matter
      Pages 95-95
    2. Ian D. Watson, David R. Jarvie, Anne Chambers, Michael J. Stewart
      Pages 103-110
    3. J. D. Robinson, I. D. Wilson, C. D. Bevan, J. Chamberlain
      Pages 111-118
  5. NOTES and COMMENTS relating to Investigation of metabolites, especially Phase I

    1. Front Matter
      Pages 135-135
    2. Yahya Y. Z. Farid, Ian D. Watson, Nigel G. L. Harding, Michael J. Stewart
      Pages 141-142
  6. Investigation of Conjugates

    1. Front Matter
      Pages 147-147
    2. John Caldwell, Andrew J. Hutt, Mary Varwell Marsh, Keith A. Sinclair
      Pages 161-179
    3. I. D. Wilson, A. Bhatti, H. P. A. Illing, T. A. Bryce, J. Chamberlain
      Pages 181-187
  7. NOTES and COMMENTS relating to Investigation of conjugates

    1. Front Matter
      Pages 189-189
  8. Determination of Particular Drugs and Metabolites

  9. NOTES and COMMENTS relating to Determination of particular drugs and metabolites

  10. Metabolite Methodology: The State-of-Play

  11. Corrections to Vol. 10, Trace-Organic Sample Handling

    1. Eric Reid, J. P. Leppard
      Pages 289-289
  12. Corrections to Vol. 11, Cancer-Cell Organelles

    1. Eric Reid, J. P. Leppard
      Pages 289-289
  13. Back Matter
    Pages 271-289

About this book

Introduction

Scope of the book, and acknowledgements.- The articles are focused on 'real problems' in body-fluid analysis, typically with a final chromatographic separation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden­ tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in therapeutic drug monitoring or in diagnosis or itself have clinical relevance, useful guidance will come from articles that follow. Authors have gone to much trouble, and are not to be blamed by any reader who would have liked an introduction to chromatography or to metabolic pathways (cf. list of conjugation reactions at end of concluding article). Appre­ ciation is also expressed for permission to reproduce published mat­ erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.

Keywords

carboxylic acid chromatography diagnosis phenol reactions society

Editors and affiliations

  • Eric Reid
    • 1
  • J. P. Leppard
    • 1
  1. 1.University of SurreyUK

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