Induced Mutagenesis

Molecular Mechanisms and Their Implications for Environmental Protection

  • Christopher W. Lawrence

Part of the Basic Life Sciences book series (volume 15)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Mutagen/DNA Interactions

  3. Infidelity and Specificity

    1. Front Matter
      Pages 61-61
    2. Thomas A. Kunkel, Roeland M. Schaaper, Elizabeth James, Lawrence A. Loeb
      Pages 63-82
    3. O. P. Doubleday, Ph. Lecomte, A. Brandenburger, W. P. Diver, M. Radman
      Pages 115-134
  4. Genetic Analysis of Mutagenesis

  5. Mammalian Systems

    1. Front Matter
      Pages 247-247
    2. Leona Samson, Jeffrey L. Schwartz
      Pages 291-309
    3. Alain Sarasin, Claire Gaillard, Jean Feunteun
      Pages 311-334
  6. Human Systems and Environmental Protection

    1. Front Matter
      Pages 335-335
    2. Herbert S. Rosenkranz, George E. Karpinsky, Monika Anders, George DeMarco, E. Joshua Rosenkranz, Lynn A. Petrullo et al.
      Pages 379-412
  7. Final Discussion: Conclusions and Synthesis

    1. Christopher W. Lawrence
      Pages 413-427
  8. Back Matter
    Pages 429-433

About this book


Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.


Hamster Mamma attention biology energy evaluation microbiology mutagen mutagenesis mutation research

Editors and affiliations

  • Christopher W. Lawrence
    • 1
  1. 1.School of Medicine and DentistryThe University of RochesterRochesterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1983
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4384-4
  • Online ISBN 978-1-4684-4382-0
  • Series Print ISSN 0066-5452
  • Buy this book on publisher's site
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