Beneficial Effects of Endotoxins

  • Alois Nowotny

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Judy A. Spitzer, John J. Spitzer
    Pages 57-74
  3. Alexander M. Abdelnoor
    Pages 75-90
  4. Erwin Neter
    Pages 91-109
  5. Abraham I. Braude, Elizabeth J. Ziegler
    Pages 111-125
  6. Ulrich H. Behling
    Pages 127-148
  7. Sheldon Edward Greisman
    Pages 149-178
  8. Masayasu Nakano, Takehiko Uchiyama
    Pages 255-272
  9. Herman Friedman, Steven Specter, R. Christopher Butler
    Pages 273-282
  10. Lawrence B. Lachman
    Pages 283-305
  11. Diane M. Jacobs
    Pages 307-325
  12. Katherine A. Gollahon, Suzanne M. Michalek, Michael J. Wannemuehler, Jerry R. McGhee
    Pages 327-353
  13. L. Joe Berry, Jeanne E. Gaska
    Pages 355-380
  14. Monto Ho
    Pages 381-395
  15. Wolfgang Hinterberger, Wolfgang Graninger, Walter R. Paukovits
    Pages 415-432
  16. Edgar Ribi, John L. Cantrell, Kuni Takayama, Ken-ichi Amano
    Pages 529-554
  17. Back Matter
    Pages 569-581

About this book


The study of endotoxins has undergone cycles of enthusiastic research followed by neglect and revival again due to newly described biological effects attributed to endotoxins. It is almost a generally applicable rule that both extremes in such fluctuations in the popularity of certain re­ search fields are unjustified. It is obvious that exaggerated expectations will lead to disappointments, and complete neglect of a once-exciting field is to be followed by renewed attention, if the scientific basis of earlier interest was solid and remained so throughout. The healing ef­ fect of fever was praised as nature's blessed cure, until it was discov­ ered that it is caused by bacteria. When it became evident that by careful application one can arrive at therapeutic doses without intro­ ducing shock and hypotension, the era of fever therapy began. During this time, indiscriminate use of pyrogens was so widespread that the high expectations had to be followed by disillusionment. Since then, in­ terest in endotoxins experienced a few more oscillations, with varying wavelengths and amplitudes, the latest being triggered by the mitotic effect of endotoxin. This led to justified excitement among researchers who study the activation of the cells of the lymphatic system and the consequences thereof, including the release of important mediator mol­ ecules. Fever therapy is passe, but the healing that often followed the ap­ plication of endotoxins remains a well-documented fact.


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Editors and affiliations

  • Alois Nowotny
    • 1
  1. 1.Center for Oral Health Research, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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