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Targeting of Drugs

  • Gregory Gregoriadis
  • Judith Senior
  • André Trouet

Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 47)

Table of contents

  1. Front Matter
    Pages i-x
  2. Macromolecular Carriers

    1. L. Fiume, C. Busi, A. Mattioli, P. G. Balboni, G. Barbanti-Brodano, Th Wieland
      Pages 1-17
    2. André Trouet, Roger Baurain, Danièle Deprez-De Campeneere, Michèle Masquelier, Philippe Pirson
      Pages 19-30
    3. T. Ghose, H. Blair, P. Kulkarni, K. Vaughan, S. Norvell, P. Belitsky
      Pages 55-82
    4. D. Caird Edwards, Philip E. Thorpe, Anthony J. S. Davies
      Pages 83-96
    5. T. A. Connors
      Pages 97-107
  3. Particulate and Cellular Carriers

  4. Liposomal Carriers

    1. Gregory Gregoriadis, Christopher Kirby, Pamela Large, Anne Meehan, Judith Senior
      Pages 155-184
    2. John N. Weinstein, Lee D. Leserman, Pierre A. Henkart, Robert Blumenthal
      Pages 185-202
    3. R. L. Magin, J. N. Weinstein
      Pages 203-221
    4. Milton B. Yatvin, Theodore C. Cree, Jerry J. Gipp
      Pages 223-234
    5. E. Mayhew, Y. M. Rustum, F. Szoka
      Pages 249-260
    6. N. van Rooijen, Ria van Nieuwmegen
      Pages 301-326
    7. Catherine Vakirtzi-Lemonias, Kalliope Sekeris-Pataryas
      Pages 355-374
  5. Back Matter
    Pages 412-430

About this book

Introduction

Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.

Keywords

Malaria antibody antigen bypass cancer cells chemistry chemotherapy drug medicine molecule protein proteins tissue vaccine

Editors and affiliations

  • Gregory Gregoriadis
    • 1
  • Judith Senior
    • 1
  • André Trouet
    • 2
  1. 1.Clinical Research CentreHarrowUK
  2. 2.International Institute of Cellular and Molecular PathologyBrusselsBelgium

Bibliographic information

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