Purine Metabolism in Man

Enzymes and Metabolic Pathways

  • Oded Sperling
  • Andre De Vries
  • James B. Wyngaarden

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Enzymes and Metabolic Pathways in Purine Metabolism

    1. Front Matter
      Pages 1-1
    2. Purine Phosphoribosyltransferases

    3. Glutamine-PRPP Amidotransferase

    4. Xanthine Oxidase

    5. PRPP Synthetase and PRPP

    6. Nucleoside and Nucleotide Metabolism

  3. Mutations Affecting Purine Metabolism

    1. Front Matter
      Pages 163-163
    2. Properties of HGPRT and APRT in HGPRT Deficient Blood Cells

    3. Purine Metabolism in HGPRT Deficient Cells

    4. Clinical Manifestations and Genetic Aspects

    5. Purine Metabolism and Erythrocyte PRPP Content in Heterozygotes for HGPRT Deficiency

    6. Mutants of PRPP Synthetase

      1. O. Sperling, S. Persky-Brosh, P. Boer, A. de Vries
        Pages 299-305
      2. Michael A. Becker, Laurence J. Meyer, Paul J. Kostel, J. Edwin Seegmiller
        Pages 307-315
    7. APRT Deficiency

      1. B. T. Emmerson, R. B. Gordon, L. Thompson
        Pages 327-331
      2. F. Delbarre, C. Auscher, B. Amor, A. de Gery
        Pages 333-339
    8. Xanthinuria

      1. D. M. Wilson, H. R. Tapia
        Pages 343-349
    9. Glycogen Storage Disease

      1. J. A. Dosman, J. C. Crawhall, G. A. Klassen, O. A. Mamer
        Pages 361-366
  4. Back Matter
    Pages xxv-xxxvi

About this book


Gout and uric acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of uric acid excretion, although still posing difficult problems, appears to approach clari­ fication.


Purine enzymes metabolism mutation synthesis

Editors and affiliations

  • Oded Sperling
    • 1
  • Andre De Vries
    • 1
  • James B. Wyngaarden
    • 2
  1. 1.Division of Metabolic Disease, Rogoff-Wellcome Medical Research InstituteBeilinson HospitalPetah-TikvaIsrael
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1974
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-3296-1
  • Online ISBN 978-1-4684-3294-7
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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