Immunologic Phylogeny

  • W. H. Hildemann
  • A. A. Benedict

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Invertebrate Immunology

    1. Front Matter
      Pages 1-1
    2. Heterophile Precipitins, Protectins, and Agglutinins

    3. Cell Surface Receptors and Recognition Factors

    4. Immunodiscrimination and Integrity of Metazoans

    5. Allogeneic Incompatibility and Transplantation Immunity

      1. Jacques L. Theodor, Jacqueline Carriere
        Pages 101-103
      2. W. H. Hildemann, D. S. Linthicum, D. C. Vann
        Pages 105-114
    6. Primordial Cell-Mediated Immunity and Memory

  3. Vertebrate Immunology

    1. Front Matter
      Pages 149-149
    2. Structure and Functions of Antibodies

      1. A. E. De Ioannes, W. H. Hildemann
        Pages 151-160
      2. L. A. Steiner, C. A. Mikoryak, A. D. Lopes, C. Green
        Pages 173-183
      3. J. P. Vaerman, J. Picard, J. F. Heremans
        Pages 185-195
      4. Renata E. Cathou, David A. Holowka
        Pages 207-215
    3. Evolution of Lymphoid and Immunocyte Systems

      1. L. William Clem, W. Edsel McLean, Vincent Shankey
        Pages 231-239
      2. D. Scott Linthicum
        Pages 241-250
      3. Bruce A. Brown, Richard K. Wright, Edwin L. Cooper
        Pages 267-275
      4. N. Donnelly, A. Brand, D. G. Gilmour
        Pages 293-302
    4. Mitogen Responsiveness, MLC Reactions, and Lymphocyte Heterogeneity

      1. Nancy H. Collins, V. Manickavel, Nicholas Cohen
        Pages 305-314
      2. S. N. Goldstine, N. H. Collins, N. Cohen
        Pages 343-351
      3. Margaret J. Manning, Madeleine H. Collie
        Pages 353-362
    5. Maturation and Modulation of Immune Functions

    6. Specific Immunoregulation and Histocompatibility Systems

About this book


There are two now classic reasons for the widespread and con­ tinuing interest in the phylogeny of immune reactivities and structure. First is the fundamental concern of biologists with the evolution of defense mechanisms. We are eager to discover origins, mechanisms, and adaptive specializations of immunocompetence because the very existence of individuals and entire species is involved in a most essential way. Second is the strong biomedical interest in adaptive immune mechanisms to increase understanding of health and disease in man. If man and placental mammals represent the quin­ tessence of immunoresponsiveness with complex interdependent path­ ways, the less elaborate but fully functional systems of immunity in "lower" animals proffer insights applicable to immediate con­ cerns in medicine. Recent approaches to organ transplantation, immunotherapy of cancer and repair of immunodeficiency diseases, to name just a few areas, have depended greatly on phylogenetic per­ spectives. In a larger sense, intelligent wildlife conservation, utilization of food resources, and adequate environmental protection all hinge on knowing how diverse species survive or otherwise suc­ cumb to insults, injuries, and disease. The phylogenetic immunologist also seeks detailed information on the structure of the immunoglobulins which relates directly to the evolutionary history of living animals. Perhaps genetic mech­ anisms responsible for the evolution of these proteins may be re­ vealed as spin-off information. The vast number of immunoglobulin specificities and effector structures, coupled with the remarkable phylogenetic conservation of certain polypeptide regions, makes these molecules especially useful to protein chemists as well as immunologists.


diseases immunity immunodeficiency immunoglobulin immunotherapy organ transplantation placenta proteins transplantation

Editors and affiliations

  • W. H. Hildemann
    • 1
  • A. A. Benedict
    • 2
  1. 1.Hilo CollegeUniversity of HawaiiHiloUSA
  2. 2.University of Hawaii at ManoaHonoluluUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1975
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-3263-3
  • Online ISBN 978-1-4684-3261-9
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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