© 1977

General Principles and Etiology

  • James G. Wilson
  • F. Clarke Fraser

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Josef Warkany
      Pages 3-45
    3. James G. Wilson
      Pages 47-74
  3. Causes of Maldevelopment

    1. Front Matter
      Pages 97-97
    2. H. V. Malling, J. S. Wassom
      Pages 99-152
    3. Robert L. Brent
      Pages 153-223
    4. Jerome E. Kurent, John L. Sever
      Pages 225-259
    5. Lucille S. Hurley
      Pages 261-308
    6. James G. Wilson
      Pages 309-355
    7. James G. Wilson
      Pages 357-385
    8. Thomas H. Shepard
      Pages 387-404
    9. Casimer T. Grabowski
      Pages 405-420
    10. Marshall J. Edwards, Raoul A. Wanner
      Pages 421-444
    11. F. Clarke Fraser
      Pages 445-463
  4. Back Matter
    Pages 465-476

About this book


In less than 40 years teratology has grown from a little known discipline concerned with studies on the effects of a few physical and chemical stresses on developing fish, amphibians, and birds, to a discipline embracing a vast accumulation of literature on experimental studies in many animal forms­ and the results of intensive scrutiny of human development under varied conditions, as well. Emphasis has shifted from preoccupation with descrip­ tions of anatomical defects to concern about subtle and interacting causative factors, to searches for the early reactions to these at the cellular and subcellu­ lar levels, and to identification of abnormality in the chemical, the functional, and the ultrastructural realms. These changes in orientation have quite naturally made necessary the recruitment of concepts, methods, and expertise from other disciplines. Hence the foundations of teratology, which once were largely morphological, have extended into genetics, biochemistry, molecular biology, reproductive physiology, epidemiology, and several aspects of veteri­ nary and clinical medicine. It is not surprising that a student or new investigator approaching the field of teratology may feel some dismay when confronted with the confusing array of cross-disciplinary concepts and principles it encompasses today. One of the aims of this work is to introduce what the editors believe is a logical thread of continuity into a field that may be regarded by some as a welter of disordered information.


biology epidemiology experiment genetics information medicine molecular biology physiology

Editors and affiliations

  • James G. Wilson
    • 1
  • F. Clarke Fraser
    • 2
    • 3
  1. 1.The Children’s Hospital Research Foundation and Department of PediatricsUniversity of CincinnatiCincinnatiUSA
  2. 2.Department of BiologyMcGill UniversityMontrealCanada
  3. 3.Department of Medical GeneticsThe Montreal Children’s HospitalMontrealCanada

Bibliographic information