Smooth Muscle

  • Edwin E. Daniel
  • David M. Paton

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Ultrastructure

    1. Front Matter
      Pages 1-1
    2. A. P. Somlyo, Avril V. Somlyo
      Pages 3-45
    3. Ruth M. Henderson
      Pages 47-77
  3. Innervation

  4. Isolation and Characterization of Contractile Proteins

    1. Front Matter
      Pages 139-139
  5. Recording of Electrical and Mechanical Activity

  6. Methods of Stimulation

    1. Front Matter
      Pages 297-297
    2. Mollie E. Holman
      Pages 299-311
    3. G. B. Weiss
      Pages 339-345
    4. W. Kosterlitz, A. J. Watt
      Pages 347-358
  7. Nerve—Muscle Preparations

    1. Front Matter
      Pages 359-359
    2. H. W. Kosterlitz, A. J. Watt
      Pages 391-401
    3. Mollie E. Holman
      Pages 403-417
    4. U. Trendelenburg, G. Haeusler
      Pages 457-468
  8. Analysis of Drug—Receptor Interaction

    1. Front Matter
      Pages 469-469
    2. D. R. Waud
      Pages 471-506
  9. Smooth Muscle Models

    1. Front Matter
      Pages 517-517
  10. Biochemical Techniques

    1. Front Matter
      Pages 541-541
    2. D. M. Paton
      Pages 613-621
    3. A. J. D. Friesen
      Pages 623-628
    4. G. Burnstock
      Pages 629-636
  11. Analysis of Ion Fluxes

    1. Front Matter
      Pages 637-637
    2. D. M. Paton
      Pages 639-645
    3. V. Palaty, S. M. Friedman
      Pages 647-661
    4. R. Casteels, G. Droogmans
      Pages 663-671

About this book


The study of the actions of drugs on smooth muscle has been a preoccupation of many pharmacologists almost from the beginning of the discipline. To a con­ siderable degree, the development of theories to explain drug actions on smooth muscle has occurred somewhat independently of the development of our knowledge of the physiology, biochemistry, and biophysics of smooth muscle. This knowledge has developed rapidly in the past decade, and some of its consequences for our understanding of drug-receptor interactions in smooth muscle have not always been fully appreciated or accepted. One of the purposes of this volume is to provide pharmacologists with some understanding of the physiology, biophysics, and bio­ chemistry of smooth muscle and of related advances in methodology so as to facilitate the incorporation of such knowledge and related methods into future pharmacological studies of smooth muscle and drug interactions. Another purpose of the book is to provide both graduate students and in­ vestigators in pharmacology and related disciplines with a summary of the numerous methods that have evolved or are available for the study of drug and smooth muscle interactions, and, in particular, to highlight their possible uses and limitations. Perhaps, because of the diversity in content and difficulty of these methods, there has to our knowledge never been a previous attempt to bring them together in one place. We have not, of course, succeeded entirely in this objective.


biochemistry chemistry drug physiology smooth muscle

Editors and affiliations

  • Edwin E. Daniel
    • 1
  • David M. Paton
    • 1
  1. 1.Department of PharmacologyThe University of AlbertaEdmontonCanada

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