Mechanisms in Fibre Carcinogenesis

1. Chemical and Physical Properties

   1. Fibre Size and Chemistry

      1. Health-Related Aspects of the Heating of Refractory Ceramic Fibre

         • J. Young, J. J. Laskowski, R. Acheson, S. D. Forder

         Pages 189-197

      2. Analysis of Polycyclic Aromatic Hydrocarbons on Vapor-Grown Carbon Fibers

         • T. C. Pederson, C. A. Powell, J. Santrock, L. Rosenbaum, J. Siak, G. G. Tibbetts et al.

         Pages 199-212

      3. Induction of Inflammation and Fibrosis after Exposure to Insoluble and Isometric Particles

         • R. Mermelstein, H. Muhle, P. Morrow

         Pages 213-228

   2. Minerology

      1. Association of Tremolite Habit with Biological Potential: Preliminary Report

         • R. P. Nolan, A. M. Langer, G. W. Oechsle, J. Addison, D. E. Colflesh

         Pages 231-251

      2. Distinguishing between Amphibole Asbestos Fibers and Elongate Cleavage Fragments of their Non-Asbestos Analogues

         • A. M. Langer, R. P. Nolan, J. Addison

         Pages 253-267

      3. Asbestiform Minerals Associated with Chrysotile from the Western Alps (Piedmont - Italy): Chemical Characteristics and Possible Related Toxicity

         • Antonella Astolfi, Bice Fubini, Elio Giamello, Marco Volante, Elena Belluso, Giovanni Ferraris

         Pages 269-283

2. Mechanisms of Pathogenesis

   1. Front Matter

      Pages 285-285

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   2. Genotoxic effects

      1. Mechanisms of Fibre Genotoxicity

         • Marie-Claude Jaurand

         Pages 287-307

      2. Asbestos Carcinogenicity: A Mutational Hypothesis

         • J. Carl Barrett

         Pages 309-318

      3. The Mutagenicity of Mineral Fibers

         • Tom K. Hei, Zhu Y. He, Chang Q. Piao, Charles Waldren

         Pages 319-325

      4. Chromosomal Damage and GAP Junctional Intercellular Communication in Mesothelioma Cell Lines and Cultured Human Primary Mesothelial Cells Treated with MMMF, Asbestos and Erionite

         • Kaija Linnainmaa, Katarina Pelin-Enlund, Kaarina Jantunen, Esa Vanhala, Timo Tuomi, Jim Fitzgerald et al.

         Pages 327-334

      5. Chrysotile, Crocidolite, and Anthophyllite Facilitation of Transfection of Cultured Mouse Cells by Polyomavirus DNA

         • George R. Dubes

         Pages 335-356

   3. Effects on Gene Expresssion

      1. Asbestos Mediated Gene Expression in Rat Lung

         • Yvonne M. W. Janssen, Joanne P. Marsh, Paul J. A. Borm, Piyawan Surinrut, Kaaren Haldeman, Brooke T. Mossman

         Pages 359-365

      2. Rat Pleural Cell Populations: Effects of MMMF Inhalation on Cytokine mRNA Expression and Population Characteristics

         • Klara Miller, B. N. Hudspith, C. Meredith

         Pages 367-376

      3. Growth Factor and Growth Factor Receptor Expression in Transformed Rat Mesothelial Cells

         • Cheryl Walker, Edilberto Bermudez, Wendy Stewart, Jeff Everitt

         Pages 377-383

   4. Fibres and free radicals

      1. The Surface Activity of Mineral Dusts and the Process of Oxidative Stress

         • H. Pezerat

         Pages 387-395

      2. Iron Mobilization from Crocidolite Results in Enhanced Iron-Catalyzed Oxygen Consumption and Hydroxyl Radical Generation in the Presence of Cysteine

         • Ann E. Aust, Loren G. Lund

         Pages 397-405

      3. The Role of Iron in the Redox Surface Activity of Fibers. Relation to Carcinogenicity

         • J. Fournier, J. Guignard, A. Nejjari, R. Zalma, H. Pezerat

         Pages 407-414

      4. Chemical Functionalities at the Broken Fibre Surface Relatable to Free Radicals Production

         • Bice Fubini, Vera Bolis, Elio Giamello, Marco Volante

         Pages 415-432

      5. Reactive Oxygen Metabolite Production Induced by Mineral Fibres

         • E. Yano, N. Urano, P. H. Evans

         Pages 433-438

The Editors are sorry that the production of this volume was delayed by the ill­ health of one of them and we hope that this does not detract from the value of the con­ tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz­ ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at­ tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.

• Pathogene
• carcinogenesis
• cell
• gene expression
• mesothelioma
• pathogenesis
• toxicity
• toxicology

• Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

  Robert C. Brown, John A. Hoskins

• Inhalation Toxicology Research Institute, Albuquerque, USA

  Neil F. Johnson

Policies and ethics