Coronaviruses

1. Virus-Cell Interaction

   1. Temperature-Sensitive Mutants of MHV-A59

      • L. S. Sturman, C. Eastwood, M. F. Frana, C. Duchala, F. Baker, C. S. Ricard et al.

      Pages 159-168

   2. Characterization of a Small Plaque Mutant of the A59 Strain of Mouse Hepatitis Virus Defective in Cell Fusion

      • Stanley G. Sawicki

      Pages 169-174

   3. The Role of Protease-Dependent Cell Membrane Fusion in Persistent and Lytic Infections of Murine Hepatitis Virus

      • Lee Mizzen, Maleki Daya, Robert Anderson

      Pages 175-186

   4. Defective Interfering Particles of Coronavirus

      • Shinji Makino, Kosaku Fujiwara, Michael M. C. Lai

      Pages 187-195

   5. Identification of a Receptor for Mouse Hepatitis Virus

      • K. V. Holmes, J. F. Boyle, D. G. Weismiller, S. R. Compton, R. K. Williams, C. B. Stephensen et al.

      Pages 197-202

   6. Analysis and Pathogenetic Significance of Class II MHC (Ia) Antigen Induction on Astrocytes During JHM Coronavirus Infection in Rats

      • Paul T. Massa, Rüdiger Dörries, Helmut Wege, Volker ter Meulen

      Pages 203-217

   7. Expression of MHC Class I Genes in Mouse Hepatitis Virus (MHV-A59) Infection and in Multiple Sclerosis

      • Ehud Lavi, Akio Suzumura, Lois A. Lampson, Richard M. Siegel, Donna M. Murasko, Donald H. Silberberg et al.

      Pages 219-222

   8. In Vivo and In Vitro Models of Demyelinating Diseases, XX: Replication of Coronaviruses in Primary Neural Cultures from Genetically Resistant and Susceptible Mice

      • Greame A. R. Wilson, Samuel Dales

      Pages 223-230

   9. Differential Effects of MHV-4 Infection of Astrocytes and Oligodendrocytes in Vitro

      • R. L. Knobler, R. Cole, J. de Vellis, H. Lewicki, M. J. Buchmeier, M. B. A. Oldstone

      Pages 231-237

   10. In Vivo and In Vitro Models of Demyelinating Disease XXI: Relationship Between Differentiation of RAT Oligodendrocytes and Control of JHMV Replication

       • Sven Beushausen, Samuel Dales

       Pages 239-254

   11. Characterization of a Non-Pathogenic MHV3 Variant Derived from a Persistently Infected Lymphoid Cell Line

       • L. Lamontagne, J. M. Dupuy

       Pages 255-263

   12. Are Differences in Biological Properties of MHV Associated with Differences in Specific Regions of their Nucleocapsid mRNA?

       • C. Kooi, T. Wallace, E. C. M. Lee Chan, V. L. Morris

       Pages 265-266

   13. Influence of the Cell Cycle on the Infectious Titer of Murine Hepatitis Virus, Strain A59

       • Pierre J. Talbot, Claude Daniel

       Pages 267-268

   14. Characterization of Temperature-Sensitive Mutants Mouse Hepatitis Virus Type 3

       • J. P. Martin, F. Koehren, A. Bingen, A. Kirn

       Pages 269-270

   15. A Cell Line Defective in Murine Coronavirus Internalization

       • Wayne F. Flintoff, Sheila Van Dinter

       Pages 271-272

   16. Regulation of Persistent Infections with Human Coronavirus OC43

       • Arlene R. Collins

       Pages 273-274

   17. Development of Rapid Assay for Screening Compounds for Antiviral Activity Against RNA Viruses

       • Sue S. Cross, Thomas W. Lewis

       Pages 275-276

2. Pathogenesis and Immunology

   1. Biology of Coronaviruses 1986

      • Volker ter Meulen

      Pages 277-286

   2. Molecular Determinants of CNS Virulence of MHV-4

      • Michael J. Buchmeier, Robert G. Dalziel, Marck J. M. Koolen, Peter W. Lampert

      Pages 287-295

   3. Maternal Antibody-Modulated MHV-JHM Infection in C57BL/6 and BALB/c Mice

      • S. Perlman, R. Schelper, D. Ries

      Pages 297-305

Coronaviruses have emerged during the past ten years from being a group of viruses causing a variety of minor veterinary and human diseases to a major virus group of both clinical significance and molecular biological interest. Against this background, two international coronavirus symposia were held in 1980 and 1983. In recent years, the pace of coronavirus research has been quickened even more by infusion of recombinant DNA technology and establishment of various animal model systems to study the pathogenesis and immunology of coronavirus infections. We therefore organized the Third International Coronavirus Symposium held at Asilomar, California in September 1986, which was attended by more than 120 participants representing a cross­ section of both academia and industry. This symposium provided an exciting and stimulating forum for assessing the progress made since the last triennial symposium in Netherlands and to suggest the directions for future efforts. This volume collects the scientific papers presented in this symposium. Three loosely defined areas, Molecular biology, Virus-Cell Interaction and Viral Pathogenesis, are separated. These papers very nicely summarize the current status of coronavirus research. They contain a large amount of sequence data, including the complete sequence of a 27 Kb coronavirus genome, a novel mechanism of mRNA synthesis that is unique to coronviruses, and many exciting aspects of coronavirus pathogenesis and immunology. Reflecting the growing interest in the preparation of vaccines, several papers also address the issues related to coronavirus vaccines, which is an area new to this symposium. Dr.

• immunology
• infection
• molecular biology
• pathogenesis
• vaccine
• virus

• University of Southern California School of Medicine, Los Angeles, USA

  Michael M. C. Lai, Stephen A. Stohlman

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