Purine and Pyrimidine Metabolism in Man V

1. Studies with Anti-Metabolites

   1. Synergy of Methotrexate and 6-Mercaptopurine on Cell Growth and Clono- Genicity of Cultured Human T-Lymphoblasts

      • Ronney A. De Abreu, Jos P. M. Bökkerink, Marinka A. H. Bakker, Tilly W. Hulscher, Gerard A. M. de Vaan, Chris H. M. M. de Bruijn et al.

      Pages 129-134

   2. Increased Availability of Phosphoribosyl Pyrophosphate as the Basis for Enhanced 6-Mercaptopurine Incorporation by Methotrexate, in Cultured Human Lymphoblasts

      • Jos P. M. Bökkerink, Ronney A. de Abreu, Jan P. R. M. van Laarhoven, Marinka A. H. Bakker, Tilly W. Hulscher, Egbert D. A. M. Schretlen et al.

      Pages 135-139

   3. Regulation of Deoxyadenosine and Nucleoside Analog Phosphorylation by Human Placental Adenosine Kinase

      • Mary C. Hurley, Bertha Lin, Irving H. Fox

      Pages 141-149

   4. The Biosynthesis of Deoxyguanosine Triphosphate in Herpes Simplex Type-1 Infected Vero Cells Treated with Acyclovir and Hydroxyurea

      • Catherine U. Lambe, Donald J. Nelson, Phillip A. Furman

      Pages 151-156

   5. 5-AZA-2′-Deoxycytidine Synergistic action with Thymidine on Leukemic Cells and Interaction of 5-AZA-dCMP with dCMP Deaminase

      • R. L. Momparler, M. Rossi, J. Bouchard, S. Bartolucci, L. F. Momparler, C. A. Raia et al.

      Pages 157-163

   6. Selection of Purine Nucleoside Analogs based on Multiple Biological and Biochemical Parameters

      • M. Jean Noujaim, George Zombor, J. Frank Henderson

      Pages 165-169

   7. Effect of m-Amsa on the Cellular Pharmacology of Ara-CTP in Human Leukemic Cells During Therapy with High-Dose Ara-C

      • William Plunkett, Michael Keating

      Pages 171-175

   8. 5-Fluoro-5′-Deoxyuridine is an Inhibitor of Uridylate Nucleotidase in L1210 Leukemaemia

      • C. Roobol, G. B. E. De Dobbeleer, J. L. Bernheim

      Pages 177-183

2. Deoxynucleotide and Nucleoside Toxicity and Metabolism

   1. The Effect of Phosphonoformic acid on Wild type and Mutant S49 Cell Lines

      • Daniel A. Albert, Lorraine J. Gudas

      Pages 185-189

   2. Mechanisms of Deoxyguanosine Toxicity for Human T and B Lymphocytes

      • J. G. M. Scharenberg, L. J. M. Spaapen, G. T. Rijkers, S. K. Wadman, G. E. J. Staal, B. J. M. Zegers

      Pages 191-199

   3. Role of Intracellular Deoxynucleoside Triphosphate Levels in DNA Repair in Human Lymphocytes

      • Amos Cohen

      Pages 201-205

   4. Genetic Analysis of Deoxyadenosine Toxicity in Dividing Human Lymphoblasts

      • Dennis A. Carson, Carlos J. Carrera, Masaru Kubota, D. Bruce Wasson, Taizo Iizasa

      Pages 207-211

   5. Inhibition of 3H-Thymidine Incorporation by Adenosine and Deoxyadenosine in Human Peripheral Lymphocytes and Malignant Lymphoid Cell Lines

      • P. M. van der Krann, P. M. van Zandvoort, R. A. De Abreu, J. A. J. M. Bakkeren, J. P. R. M. van Laarhoven, C. H. M. M. de Bruijn

      Pages 213-219

   6. S-Adenosylmethionine Metabolism as a Target for Adenosine Toxicity

      • E. Olavi Kajander, Masaru Kubota, Eric H. Willis, Dennis A. Carson

      Pages 221-226

   7. Ethanol Induced Nucleotide Catabolism in Mouse T Lymphoblastoid Cells in Vitro

      • Jerzy Barankiewicz, Amos Cohen

      Pages 227-230

   8. Increased Level of Ribonucleotide Reductase in Deoxyadenosine Resistant Adenosine Deaminase Deficient Human Histiocytic Lymphoma Cells

      • Yvonne Dahbo, Dennis Carson, Staffan Eriksson

      Pages 231-234

   9. Inhibition of T Cell Cytotoxicity by Cyclosporine (CSA), Adenosine (ADO) and an Inhibitor of Adenosine Deaminase (ADA)

      • Caliann T. Lum, Stephen R. Jennings, Frederick J. Wanner, Satvir S. Tevethia

      Pages 235-238

3. Enzymes

   1. Mechanism of Urate Production by Guinea-Pig Ileum

      • D. R. Webster, G. D. Boston, D. M. Paton

      Pages 239-243

   2. In Vitro Degradation of Pyrimidine Bases: Studies of Rat Liver Dihydropyrimidine Dehydrogenase

      • Mendel Tuchman, Margaret L. Ramnaraine, Robert F. O’Dea

      Pages 245-248

   3. Regulation of Enzymes by Ligand Induced Change in Polymerization

      • Thomas W. Traut, Nancy Cheng, Margaret M. Matthews

      Pages 249-254

The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U. S. A. ) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it per­ mitted us to honor Dr. J. E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W. E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr. , was scheduled to be the speaker at our banquet. Unfortunate­ ly, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been pub­ lished following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive.

• growth
• infection
• interferon
• leukemia
• medicine
• metabolism
• muscle
• pharmacology
• research
• surgery

• University of California, San Diego La Jolla, USA

  W. L. Nyhan

• Scripps Clinic and Research Foundation, La Jolla, USA

  L. F. Thompson

• M. R. C. Clinical Research Center, Harrow, UK

  R. W. E. Watts

Policies and ethics