© 1979

Cell Substrates

Their Use in the Production of Vaccines and Other Biologicals

  • John C. Petricciani
  • Hope E. Hopps
  • Paul J. Chapple

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 118)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Past Achievements — Future Expectations

    1. Harry M. Meyer Jr.
      Pages 1-5
  3. Cell Substrates: General Overview

  4. Viral Vaccine Substrates

  5. Cell Substrates for Biologicals other than Vaccines

    1. Jan Vilček
      Pages 115-116
    2. Jan Vilcek
      Pages 117-127
    3. Joseph C. Fratantoni
      Pages 129-133
    4. Donald K. Dougall
      Pages 135-152
    5. Robert R. Wagner
      Pages 175-183
  6. Summary and Considerations for the Future

    1. Thomas C. Merigan
      Pages 185-185
    2. H. Bruce Dull
      Pages 187-193

About this book


This volume stems from a symposium sponsored by the W. Alton Jones Cell Science Center, Lake Placid New York. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and­ Their Use in the Production of Vaccines and Other Biologicals was held October 23-26, 1978. The Center is an operational unit of the Tissue Culture Association and offers, in collaboration with the Association's Education Committee, a wide range of educational and research activities. During the past 20 years there have been numerous national and international conferences on the topic of cell cultures used to produce biological products. Those largely dealt with the technology and associated issues that were current at the time of the meetings. For example, as human diploid cells were developed and proposed for use in vaccine production, a number of meetings were held to examine the pros and cons of human diploid cells. A large amount of data was provided at those conferences which formed the basis for the eventual acceptance of that cell system. Each meeting added to the general base of knowledge in the area of cell cultures and their application to the current and novel set of problems encountered. In general, the participants reaffirmed the basic premises that were formulated in the early days of polio virus vaccine production regarding the criteria for acceptability of cells when used in the manufacture of biologics intended for humans.


cell cell culture research tissue vaccine

Editors and affiliations

  • John C. Petricciani
    • 1
  • Hope E. Hopps
    • 1
  • Paul J. Chapple
    • 2
  1. 1.Bureau of Biologics of the Food and Drug AdministrationBethesdaUSA
  2. 2.W. Alton Jones Cell Science CenterLake PlacidUSA

Bibliographic information

  • Book Title Cell Substrates
  • Book Subtitle Their Use in the Production of Vaccines and Other Biologicals
  • Editors J. C. Petricciani
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer-Verlag US 1979
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-40189-3
  • Softcover ISBN 978-1-4684-0999-4
  • eBook ISBN 978-1-4684-0997-0
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages VIII, 220
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
    Cell Biology
  • Buy this book on publisher's site
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