© 1979

Methods in Membrane Biology

Volume 10

  • Edward D. Korn

Table of contents

  1. Front Matter
    Pages i-xiv
  2. D. Papahadjopoulos, G. Poste, W. J. Vail
    Pages 1-121
  3. Sidney J. Socolar, Werner R. Loewenstein
    Pages 123-179
  4. Back Matter
    Pages 223-227

About this book


Three articles make up Volume 10 of Methods in Membrane Biology. In the first of these, Papahadjopoulos, Poste, and Vail extensively review much of the available data on the fusion of natural membranes, model membranes (liposomes), and natural membranes with liposomes. The authors are led by their review of the experimental methods and their interpretations of the results obtained to a general theory of membrane fusion which they believe is applicable to all systems that have been studied. Arguing that although protein and carbohydrate may serve, in some cases, to bring membranes into sufficiently close proximity for fusion to occur and, in other cases, to remove peripheral and integral proteins from the regions that are to undergo fusion, the authors conclude that membrane fusion per se is solely a property of the lipid bilayer. In their view, all the experimental observations to date can be subsumed under a unifying hypothesis in which membrane fusion is the result of a phase separation in one-half of the membrane bilayer brought about by the interaction - of calcium ions with acidic phospholipids, mostly phosphatidylserine. Where half-membranes already contain sufficient acidic phospholipids, a local increase in calcium ion concentration may suffice to induce fusion (examples might include exocytosis and fusion of intracellular membrane systems). In other cases, natural or experimentally induced events preceding fusion might be necessary to increase the local concentration of the acidic phospholipids in the half-membrane (virus-or fusogenic agent-induced cell-to-cell fusion, or endocytosis, for example).


Calcium Lipid biology protein proteins

Editors and affiliations

  • Edward D. Korn
    • 1
  1. 1.Laboratory of Cell BiologyNational Heart and Lung InstituteBethesdaUSA

Bibliographic information

  • Book Title Methods in Membrane Biology
  • Book Subtitle Volume 10
  • Authors Edward D. Korn
  • DOI
  • Copyright Information Springer-Verlag US 1979
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-40126-8
  • Softcover ISBN 978-1-4684-0987-1
  • eBook ISBN 978-1-4684-0985-7
  • Edition Number 1
  • Number of Pages XIV, 227
  • Number of Illustrations 23 b/w illustrations, 0 illustrations in colour
  • Topics Biochemistry, general
  • Buy this book on publisher's site
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