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Mechanisms of Stimulus—Response Coupling in Platelets

  • J. Westwick
  • M. F. Scully
  • D. E. MacIntyre
  • V. V. Kakkar

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 192)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Platelet Receptors

    1. Thomas C. Detwiler, Eleanor B. McGowan
      Pages 15-28
    2. Noel J. Cusack, Susanna M. O. Hourani, Laurence A. Welford
      Pages 29-39
    3. Gérard A. Marguerie, Mark. H. Ginsberg, Edward F. Plow
      Pages 41-54
    4. Sandor S. Shapiro
      Pages 55-66
    5. R. L. Jones, N. H. Wilson, Roma A. Armstrong
      Pages 67-81
    6. D. P. Tuffin, P. Davey, R. L. Dyer, D. O. Lunt, P. J. Wade
      Pages 83-96
    7. D. B. Barnett, S. S. Swart, S. R. Nahorski, N. Cook
      Pages 97-108
    8. B. J. R. Whittle, S. Hamid, P. Lidbury, A. C. Rosam
      Pages 109-125
  3. Control of Calcium Mobilization

    1. D. Euan MacIntyre, W. Kenneth Pollock, Angus M. Shaw, Mark Bushfield, Linda J. MacMillan, Archibald McNicol
      Pages 127-144
    2. Edwin W. Salzman, Peter C. Johnson, J. Anthony Ware
      Pages 163-170
    3. Michael C. Scrutton, Derek E. Knight, Verena Niggli
      Pages 171-183
    4. F. Carey, S. Menashi, K. S. Authi, N. Hack, M. Lagarde, N. Crawford
      Pages 185-199
  4. Phosphorylation of Platelet Proteins and Nucleotide Metabolism

    1. Holm Holmsen, Anna Opstvedt Nilsen, Sissel Rongved
      Pages 215-233
    2. J. M. Gerrard, L. L. Friesen, J. M. McCrea, S. J. Israels, P. Robinson
      Pages 235-248
    3. M. Castagna, R. Brasseur, C. Pavoine, R. Bredoux, B. Mely, J. M. Ruysschaert et al.
      Pages 249-263
    4. Richard J. Haslam, Kimberley A. Williams, Monica M. L. Davidson
      Pages 265-280
  5. Products of Phospholipid Metabolism

    1. J. Bryan Smith, C. Dangelmaier, A. D. Purdon, G. Mauco
      Pages 281-291
    2. John Ambler, Jill Birch, Eric D. Maguire, Robert B. Wallis
      Pages 293-308
    3. Michel Chignard, Eliane Coëffier, Jacques Benveniste
      Pages 309-326
    4. Michel Lagarde, Martine Croset, Michel Guichardant, Marc Dechavanne
      Pages 327-335
    5. Salvador Moncada, Brendan J. R. Whittle
      Pages 337-358
  6. Functional Platelet Responses

    1. Edouard M. Bevers, Jan Rosing, Robert F. A. Zwaal
      Pages 359-371
    2. Vincent Ellis, M. F. Scully, V. V. Kakkar
      Pages 373-387
    3. M. F. Scully, K. M. Weersinghe, V. V. Kakkar
      Pages 389-398
    4. R. M. Hardisty
      Pages 411-418
  7. Back Matter
    Pages 439-444

About this book

Introduction

Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri­ butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con­ trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate­ lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan­ isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell­ ular response by protein phosphorylation and calcium flux. The mech­ anism of these latter events occurs through the activity of phospho­ lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico­ sanoids, reinforce and make irreversible the cellular response.

Keywords

Ether Lipid Nucleotid Protein behavior cell development etiology inflammatory response medicine oxygen phosphorylation platelets receptor synthesis

Editors and affiliations

  • J. Westwick
    • 1
  • M. F. Scully
    • 2
  • D. E. MacIntyre
    • 3
  • V. V. Kakkar
    • 2
  1. 1.Department of PharmacologyRoyal College of SurgeonsLondonEngland
  2. 2.Thrombosis Research UnitKing’s College School of Medicine and DentistryLondonEngland
  3. 3.Department of PharmacologyUniversity of GlasgowGlasgowScotland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-9442-0
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-9444-4
  • Online ISBN 978-1-4615-9442-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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