New Frontiers and Advances

  • H. Hugh Fudenberg
  • H. D. Whitten
  • Fabio Ambrogi

Table of contents

  1. Front Matter
    Pages i-x
  2. Thymus Hormone or Extracts

    1. M. G. Bernengo, F. Lisa, P. Fra, M. Meregalli, M. Novelli, G. Zina
      Pages 43-67
    2. P. Rambotti, A. Velardi, M. F. Martelli, C. Cernetti, F. Spinozzi, F. Grignani et al.
      Pages 69-83
  3. Dialyzable Leukocyte Extracts and Immune RNA

    1. John A. Mannick, Bosco S. Wang, Glenn D. Steele, Jerome P. Richie
      Pages 85-104
    2. Maria Caterina Sirianni, R. Paganelli
      Pages 105-114
    3. H. H. Fudenberg, G. B. Wilson, K. Y. Tsang
      Pages 115-130
  4. Interferon

  5. Bacterial Products

    1. Ruben A. Binaghi, Fabrizio Bruschi, Stella Maris Venturiello
      Pages 197-208
    2. Herman Friedman, Thomas Klein, R. Christopher Butler
      Pages 209-228
    3. Y. Yamamura, I. Azuma
      Pages 249-256
  6. Cell Interactions

    1. J. P. R. M. van Laarhoven, C. H. M. M. De Bruyn, H. Collet, G. Delespesse
      Pages 257-267
    2. M. Piantelli, P. Mussiani, L. Lauriola, N. Maggiano, F. O. Ranelletti
      Pages 269-277
  7. Effects of Chemically Synthesized Immunomodulators

    1. Aldo Tagliabue, Saverio Alberti, Walter Luini, Luciano Nencioni, Diana Borashi
      Pages 293-302
    2. G. S. Del Giacco, F. Locci, L. Cengiarotti, E. Chessa, A. Di Tucci, G. Meloni et al.
      Pages 303-309
    3. Federico Spreafico, Annunciata Vecchi
      Pages 311-329
    4. T. Ginsberg, J. W. Hadden
      Pages 331-348
    5. Joseph Wybran, Thierry Appelboom
      Pages 363-374
    6. C. De Simone, S. Zansoglu, L. Pugnaloni, F. Sorice
      Pages 375-384
    7. Massimo Galli, Adriano Lazzarin, Mauro Moroni, Carlo Zanussi
      Pages 385-397
  8. Monoclonal Antibodies in Treatment and Diagnosis

    1. Lucienne Chatenoud, Marc Baudrihaye, Nadira Chkoff, Henri Kreis, Jean-Francois Bach
      Pages 399-405
    2. G. Corte, A. Moretta, D. Ramarli, G. W. Canonica, A. Bargellesi
      Pages 407-412
  9. Autoimmunity

    1. Alberto M. Marmont
      Pages 427-434
  10. Back Matter
    Pages 435-458

About this book


On May 14-16, 1982, a group of scientists met in Viareggio, Italy to present ideas, and exchange relevant data on current approaches on immunomodulators. We felt that the embodiment of the substance of that international symposium into this volume will be beneficial in keeping both clinicians and basic scientists abreast of the latest exciting developments in this rapidly accelerating field. We hope that the publication of this series of papers by an international panel of experts will enhance the nature of future inves t igat ive stud ies with such ent it ies . Under the rubric of immunology, it is obvious that such a term as "immunomodulation" could be construed as being all encompassing. However, it is intriguing that the immune modulators touched on in these sessions can be subcategorized into about five broad groups. Almost all substances, excepting those entities that are immuno­ logically inert, will have some modulating effects on immunity. From the coarse adjustment of antibody feedback inhibition upon cellular limnunity to the subtle finesse envisioned in Jerne's idiotypic network and s'lppressor T cells, immunomodulators attempt to either magnify or diminish those responses that are normally elicited by antigen. The broad groups - thymic hormones, D.L.E., Interferon, drugs, and the use of bacterial products appear to be at the forefront of much of the pioneering work on immunomodulation.


antibody antigen bacteria immunity immunology interferon

Editors and affiliations

  • H. Hugh Fudenberg
    • 1
  • H. D. Whitten
    • 1
  • Fabio Ambrogi
    • 2
  1. 1.Medical University of South CarolinaCharlestonUSA
  2. 2.University of PisaPisaItaly

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