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PROTEASES: Potential Role in Health and Disease

  • Book
  • © 1984

Overview

Editors:
  1. Walter H. Hörl

    1. University of Würzburg, Würzburg, Federal Republic of Germany

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  2. August Heidland

    1. University of Würzburg, Würzburg, Federal Republic of Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 167)

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Table of contents (51 chapters)

  1. Proteases and Blood System

    1. The Calcium-Dependent Neutral Protease of Human Blood Platelets: A Comparison of its Effects on the Receptors for von Willebrand Factor and for the Fc-Fragment Derived from IgG

      • M. O. Spycher, U. E. Nydegger, E. F. Luescher
      Pages 241-251

    2. Alpha-2-Plasmin-Inhibitor Inactivation by Human Granulocyte Elastase

      • M. Gramse, K. Havemann, R. Egbring
      Pages 253-261

    3. Heparin and Plasma Proteinase Inhibitors: Influence of Heparin on the Inhibition of Thrombin by α2 Macroglobulin

      • P. Lambin, F. Pochon, M. Steinbuch
      Pages 263-272

    4. The Involvement of Plasmatic and Fibrinolytic Systems in Idiopathic Glomerulonephritis (GN)

      • K. Andrassy, E. Ritz, R. Waldherr
      Pages 273-285

    5. The Effect of Aprotinin on Platelet Function, Blood Coagulation and Blood Lactate Level in Total Hip Replacement - A Double Blind Clinical Trial

      • S. Haas, R. Ketterl, A. Stemberger, P. Wendt, H.-M. Fritsche, H. Kienzle et al.
      Pages 287-297

  2. Proteases and Lung

    1. Interaction of Granulocyte Proteases with Inhibitors in Pulmonary Diseases

      • Kjell Ohlsson, Ulla Fryksmark, Mats Ohlsson, Hans Tegner
      Pages 299-312

    2. Leukoproteinases and Pulmonary Emphysema: Cathepsin G and other Chymotrypsin-Like Proteinases Enhance the Elastolytic Activity of Elastase on Lung Elastin

      • Christian Boudier, Philippe Laurent, Joseph G. Bieth
      Pages 313-317

    3. Adult Respiratory Distress Syndrome (ARDS): Experimental Models with Elastase and Thrombin Infusion in Pigs

      • H. Burchardi, T. Stokke, I. Hensel, H. Köstering, G. Rahlf, G. Schlag et al.
      Pages 319-333

  3. Proteases and Arthritis

    1. Interactions of Granulocyte Proteases with Inhibitors in Rheumatoid Arthritis

      • Lars Ekerot, Kjell Ohlsson
      Pages 335-344

    2. Quantitation of Human Leukocyte Elastase, Cathepsin G, α-2-Macro-Globulin and α-1-Proteinase Inhibitor in Osteoarthrosis and Rheumatoid Arthritis Synovial Fluids

      • G. D. Virca, R. K. Mallya, M. B. Pepys, H. P. Schnebli
      Pages 345-353

    3. Plasma Levels of Inhibitor-Bound Leukocytic Elastase in Rheumatoid Arthritis Patients

      • H. P. Schnebli, P. Christen, M. Jochum, R. K. Mallya, M. B. Pepys
      Pages 355-362

    4. a2M-Pasebic Assay: A Solid Phase Immunosorbent Assay to Characterize Alpa2-Macroglobulin - Proteinase Complexes and the Proteinase Binding-Capacity of Alpha2 -Macroglobulin

      • Wolfgang Borth
      Pages 363-369

    5. Role of Alpha2 -Macroglobulin: Proteinase Complexes in Pathogenesis of Inflammation - ‘F’ a2M But not ‘s’ a2M Induces Synovitis in Rabbits after Repeated Intra-Articular Administration

      • Wolfgang Borth, Martin Susani
      Pages 371-377

  4. Hypercatabolism

    1. Enzyme-Linked Immunoassay for Human Granulocyte Elastase in Complex with α1 -Proteinase Inhibitor

      • Siegfried Neumann, Norbert Hennrich, Gerhard Gunzer, Hermann Lang
      Pages 379-390

    2. Proteinases and their Inhibitors in Septicemia - Basic Concepts and Clinical Implications

      • M. Jochum, K.-H. Duswald, S. Neumann, J. Witte, H. Fritz
      Pages 391-404

    3. Proteolytic Activity in Patients with Hypercatabolic Renal Failure

      • Walter H. Hörl, Roland M. Schäfer, Klemens Scheidhauer, Marianne Jochum, August Heidland
      Pages 405-416

    4. Release of Granulocyte Neutral Proteinases in Patients with Acute and Chronic Renal Failure

      • August Heidland, Walter H. Hörl, Norbert Heller, Harmut Heine, Siegfried Neumann, Ekkehard Heidbreder
      Pages 417-431

    5. Changes in Components of The Plasma Kallikrein-Kinin and Fibrinolytic Systems Induced by a Standardized Surgical Trauma

      • A. O. Aasen, J. Stadaas, T. E. Ruud, P. Kierulf
      Pages 433-437

    6. Endotoxins and Coagulation Parameters in Patients with Traumatic Haemorrhagic- and Bacteriotoxic Shock

      • A. Stemberger, F. Strasser, G. Blümel, B. V. Hundelshausen, S. Jelen, O. Schmidt et al.
      Pages 439-448

    7. Studies on Pathological Plasma Proteolysis in Severely Burned Patients using Chromogenic Peptide Substrate Assays: A Preliminary Report

      • T. E. Ruud, P. Kierulf, H. C. Godal, S. Aune, A. O. Aasen
      Pages 449-454
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Keywords

About this book

We are pleased to present to our readers the Proceedings of the International Symposium "Proteases: Potential Role in Health and Disease" which was held in WUrzburg (FRG) during October 17-20, 1982. The topics discussed included those dealing with the physi­ ology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-kinin system, complement and the coagulation system, the function of proteases in the kidney and the intestinal tract as well as the role of proteases in lung diseases, pancreatitis, arthritis and hypercatabolic states (multiple trauma, septicemia, acute renal failure). The papers presented answered many questions, but raised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortunately impossible in this volume to in­ clude the extended, lively and extremely stimulating discussions which were enjoyed by the participants during the conference. The meeting has provided a unique framework for close inter­ action between scientists from various disciplines, including bio­ chemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pulmonology and nephrology. We would like to express our thanks and appreciation for all those who have stimulated, encouraged and supported us to hold this symposium in WUrzburg. This endeavor could not have been possible without the generous financial support of the Paul-Martini­ Foundation (Mainz), Bayer AG (Leverkusen), Beiersdorf AG (Hamburg).

Editors and Affiliations

  • University of Würzburg, Würzburg, Federal Republic of Germany

    Walter H. Hörl, August Heidland

Bibliographic Information

  • Book Title: PROTEASES: Potential Role in Health and Disease

  • Editors: Walter H. Hörl, August Heidland

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-9355-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1984

  • Softcover ISBN: 978-1-4615-9357-7Published: 25 November 2012

  • eBook ISBN: 978-1-4615-9355-3Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 591

  • Topics: Biochemistry, general

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

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